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Accumulation and Metabolism of Fluoride from Antarctic Krill (Euphausia Superba) in Rats

文献类型： 外文期刊

作者： Zhu, Lanlan 1 ; Hou, Zhongling 3 ; Leng, Kailiang 2 ; Liu, Zhantao 5 ;

作者机构： 1.Shandong Univ Technol, Sch Agr Engn & Food Sci, Zibo, Peoples R China

2.Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao, Shandong, Peoples R China

3.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai, Peoples R China

4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao, Shandong, Peoples R China

5.Qiingdao Univ, Sch Pharm, Qingdao, Shandong, Peoples R China

关键词： Antarctic Krill; Fluoride; Accumulation; Toxicity; Rats

期刊名称：REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS （ 影响因子：0.444； 五年影响因子：0.473 ）

ISSN： 0798-2259

年卷期： 2019 年 29 卷 5 期

页码：

收录情况： SCI

摘要： Fluorine is an essential element for living organisms, but it also needs to be limited in intake The occurrence form of fluorine has a significant effect on its toxicity. The occurrence form of fluorine in Antarctic krill is complex, and its toxicity can not be simply equal to that of normal food. A view of its broad application prospects in food, it is necessary to evaluate the acute and chronic toxicity of fluoride in Antarctic krill from the perspective of accumulation and metabolism. In acute toxicity test, the maximum dosage of Antarctic krill powder was 20g/kg Bw, and the oral lethal dose of Antarctic krill powder was LD50 > 20g/kg Bw. Fluoride in Antarctic krill meal had no significant effect on the lipid metabolism related indicators of the tested animals, but it could cause oxidative stress reaction in the tested animals and reduce the antioxidant capacity of the body; and it could cause potential kidney damage and clear liver damage through oxidative stress reaction. Fluoride in Antarctic phosphatide powder accumulated significantly in bone and teeth, but the degree of fluoride accumulation was significantly weaker than that of sodium fluoride; in organs vulnerable to oxidative stress, fluoride in Antarctic krill only showed slight accumulation in lungs, similar to that in sodium fluoride level, but not significant; fluoride and sodium fluoride in Antarctic krill accumulated slightly in other soft tissues such as brain, spleen, heart and brain. No accumulation was found in testes and ovaries of reproductive organs.

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