lakyricidins A-D, Antiproliferative Piericidin Analogues Bearing a Carbonyl Group or Cyclic Skeleton from Streptomyces iakyrus SCSIO NS104
文献类型： 外文期刊
作者： Li, Kunlong 1 ; Liang, Zhi 3 ; Chen, Weihao 1 ; Luo, Xiaowei 1 ; Fang, Wei 4 ; Liao, Shengrong 1 ; Lin, Xiuping 1 ; Yang, 1 ;
作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Biopharmaceut, Guangzhou 510515, Guangdong, Peoples R China
4.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Hubei, Peoples R China
期刊名称：JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：4.354； 五年影响因子：4.082 ）
ISSN： 0022-3263
年卷期： 2019 年 84 卷 19 期
页码：
收录情况： SCI
摘要： Iakyricidins A-D (1-4), a carbonyl-containing piericidin derivative and three novel piericidin analogues bearing cyclic skeletons, were isolated from the mangrove sediment derived strain Streptomyces iakyrus SCSIO NS104. These structures were established by spectroscopic techniques, Moshers method, and ECD calculations. Compounds 2-4 represent a novel skeleton of piericidins with branched chain C-C cyclization, and their biosynthetic pathways are proposed. Compound 1, the first natural carbonyl-containing piericidin derivate, exhibited potent antiproliferative activity against ACHN with an IC50 value of 20 nM.
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