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Development of chimeric virus-like particles containing the E glycoprotein of duck Tembusu virus

文献类型： 外文期刊

作者： Li, Linlin 1 ; Zhang, Yun 2 ; Dong, Jiawen 1 ; Zhang, Junqing 1 ; Zhang, Chunhong 1 ; Qin, Jianru 2 ; Sun, Minhua 1 ; Xu, 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Livestock Dis Prevent, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Minist Agr,Inst Anim Hlth,Guangdong Open Lab Vet, Baishigang Rd, Guangzhou, Guangdong, Peoples R China

2.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510006, Guangdong, Peoples R China

关键词： Duck Tembusu virus (DTMUV); E protein; Virus-like particles (VLPs)

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2019 年 238 卷

页码：

收录情况： SCI

摘要： Duck Tembusu virus (DTMUV) has caused enormous economic losses to the poultry industry in China. In the current study, we generated chimeric virus-like particles (VLPs) containing E protein of the DTMUV and HA2 protein of the H3N2 avian influenza virus (AIV). The chimeric VLPs could induce specific antibody responses in both mice (n = 5/group) and ducks (n = 10/group). After immunizing ducklings with the chimeric VLPs, all immunized ducks (n = 10/group) were 100% (10/10) protected against homologous DTMUV strain and virus shedding was not detected on day 5 post-challenge, whereas 60% (6/10) of the ducklings immunized with PBS presented typical symptoms with a virus shedding rate of 90% (9/10). Furthermore, viral loads were significantly decreased in the birds of the chimeric VLPs immunized group, comparing to that of the PBS immunized group. Our data demonstrated that the chimeric VLPs used in the current study could be applied as a potential vaccine candidate to control DTMUV infections in young ducks.

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