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LC-MS guided identification of dimeric 2-(2-phenylethyl)chromones and sesquiterpene-2-(2-phenylethyl)chromone conjugates from agarwood of Aquilaria crassna and their cytotoxicity

文献类型： 外文期刊

作者： Xia, Lulu 1 ; Li, Wei 1 ; Wang, Hao 1 ; Chen, Huiqin 1 ; Cai, Caihong 1 ; Yang, Li 1 ; Jiang, Bei 3 ; Yang, Yiling 3 ; Mei, 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Engn Res Ctr Agarwood, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

2.Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

3.Dali Univ, Coll Pharm & Chem, Inst Mat Med, Dali 671003, Peoples R China

关键词： Agarwood; Aquilaria crassna; Dimeric 2-(2-phenylethyl)chromone; Sesquiterpene-2-(2-phenylethyl)chromone conjugate; Cytotoxic activity

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2019 年 138 卷

页码：

收录情况： SCI

摘要： Four previously unreported dimeric 2-(2-phenylethyl)chromones (1-4a) and three unprecedented sesquiterpene-2-(2-phenylethyl)chromone conjugates (5-7), comprising a sesquiterpenoid and a 5,6,7,8-tetrahydroxy-2-(2-phenylethyl)-5,6,7,8 -tetrahydro-4H-chromone moiety, as well as three known dimeric 2-(2-phenylethyl) chromones (4b, 8a, 8b) were identified from agarwood originating from Aquilaria crassna in Cambodia by LC-MS guided separation. Their structures were elucidated by extensive NMR techniques, HRESIMS and CD. All compounds were evaluated for their cytotoxicity against four human cancer cell lines. Compounds 6, 7, 8a, 8b displayed a range of cytotoxic activities with IC50 values in the rang 10.93-49.0 mu M

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