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MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice

文献类型： 外文期刊

作者： Gan, Mailin 1 ; Shen, Linyuan 1 ; Fan, Yuan 1 ; Tan, Ya 1 ; Zheng, Ting 1 ; Tang, Guoqing 1 ; Niu, Lili 1 ; Zhao, Ye 1 ; Che 1 ;

作者机构： 1.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Sichuan, Peoples R China

2.Sichuan Agr Univ, Farm Anim Genet Resource Explorat & Innovat Key L, Chengdu 611130, Sichuan, Peoples R China

3.Guizhou Acad Agr Sci, Inst Anim Husb & Vet, Guiyang 550005, Guizhou, Peoples R China

关键词： miR-451; genistein; NASH; hepatocarcinoma

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN：

年卷期： 2019 年 20 卷 23 期

页码：

收录情况： SCI

摘要： Effective, targeted therapy for chronic liver disease nonalcoholic steatohepatitis (NASH) is imminent. MicroRNAs (miRNAs) are a potential therapeutic target, and natural products that regulate miRNA expression may be a safe and effective treatment strategy for liver disease. Here, we investigated the functional role of miR-451 and the therapeutic effects of genistein in the NASH mouse model. MiR-451 was downregulated in various types of liver inflammation, and subsequent experiments showed that miR-451 regulates liver inflammation via IL1 beta. Genistein is a phytoestrogen with anti-inflammatory and anti-oxidant effects. Interestingly, we found that the anti-inflammatory effects of genistein were related to miR-451 and was partially antagonized by the miR-451 inhibitor. MiR-451 overexpression or genistein treatment inhibited IL1 beta expression and inflammation. Taken together, this study shows that miR-451 has a protective effect on hepatic inflammation, and genistein can be used as a natural promoter of miR-451 to ameliorate NASH.

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