文献类型： 外文期刊
作者： Li, Linlin 2 ; Zhang, Yun 1 ; Dong, Jiawen 2 ; Zhang, Junqing 2 ; Zhang, Chunhong 2 ; Sun, Minhua 2 ; Cao, Yongchang 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510006, Peoples R China
2.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Livestock Dis Prevent, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Minist Agr,Guangdong Open Lab Vet Publ Hlth,Inst, Baishigang Rd, Guangzhou, Guangdong, Peoples R China
关键词： Duck Tembusu virus (DTMUV); Envelope (E) protein; Truncated E protein
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）
ISSN： 0378-1135
年卷期： 2020 年 240 卷
页码：
收录情况： SCI
摘要： Duck Tembusu virus (DTMUV) is a major pathogen of duck industry in China. In the current study, we generated different constructs containing envelope (E) protein, pre-membrane-envelope (prM-E) protein, and C-terminally truncated E protein of the DTMUV. The constructed proteins could induce specific antibody responses in young ducks. When ducklings were immunized with the constructed proteins, they were 100% protected against DTMUV infection. Furthermore, the fluorescent signal of the truncated E protein was stronger than other constructed proteins, when Bac-to-Bac baculovirus expression system was applied. Our data demonstrated that the truncated E protein used in the current study could be applied as a potential vaccine candidate to control DTMUV infection in young ducks.
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