Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3K-AKT related signal pathway in SMMC7721 cancer cells
文献类型： 外文期刊
作者： Zhang, Hui-xing 1 ; Kang, You 4 ; Li, Ning 1 ; Wang, Hai-feng 1 ; Bao, Yong-rui 2 ; Li, Yan-wu 2 ; Li, Xue-zheng 3 ; Jian 1 ;
作者机构： 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Wenhua Rd 103, Shenyang 110016, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China
3.Yanbian Univ Hosp, Dept Pharm, Yanji 133000, Peoples R China
4.Jilin Acad Agr Sci, Northeast Agr Res Ctr China, Changchun 130033, Peoples R China
关键词： Hamamelidaceae; Liquidambaris fructus; Triterpenoids; Apoptosis; PI3K-AKT pathway
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）
ISSN： 0031-9422
年卷期： 2020 年 171 卷
页码：
收录情况： SCI
摘要： A previously undescribed taraxerene-type triterpenoid possessing a class of rare natural taraxerene triterpenoid possessing skeleton with 14, 28-lactone, two undescribed oleane-type triterpenoids, and twenty-five known triterpenoids were isolated from Liquidambar formosana (Hamamelidaceae). The structures of undescribed compounds were determined on the basis of 1D and 2D NMR spectroscopic, HR-ESI-MS, and X-ray crystallographic data analysis. Among the isolates, ursolic acid, 3,6-dion-20(29)-lupen-28-oic acid, and 3-oxo-12 alpha-hydroxyoleanan-28,13 beta-olide induced a significant apoptosis in SMMC7721 cells in the flow cytometer experiment with apoptosis rates of 94.5%, 57.3% and 89.9% at 8.0 mu M, respectively, exhibiting near equivalent apoptosis-inducing abilities to that positive drug taxol (apoptotic rate of 71.2% at 1.4 mu M). Mechanism studies suggested that these three compounds could regulate the mitochondrial pathway by up-regulating the expressions of pro-apoptotic factors (Bad and Bax) and activating caspase-3 and caspase-9 to induce apoptosis. Further studies indicated that the pro-apoptotic effects of these three compounds were associated with PI3K-AKT pathway inhibition. Taken together, these studies provide evidence that triterpenoids from L. Fructus are promising candidates for the hepatocellular carcinoma therapy.
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