Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
文献类型： 外文期刊
作者： Zhang, Fei 1 ; Zhou, Liman 1 ; Kong, Fandong 1 ; Ma, Qingyun 1 ; Xie, Qingyi 1 ; Li, Jiuhui 1 ; Dai, Haofu 1 ; Guo, Lei 2 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
2.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Jiangsu Key Lab Marine Bioresources & Environm, Lianyungang 222005, Peoples R China
关键词： Cladosporium sp.; altertoxins; quorum sensing inhibitory activity
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN：
年卷期： 2020 年 18 卷 1 期
页码：
收录情况： SCI
摘要： Five new perylenequinone derivatives, altertoxins VIII XII (1-5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1-6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 pg/well, respectively.
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