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Effect of vitamin D-3 on the immunomodulation of head kidney after Edwardsiella ictaluri challenge in yellow catfish (Pelteobagrus fulvidraco)

文献类型： 外文期刊

作者： Cheng, Ke 1 ; Tang, Qin 2 ; Huang, Yanqing 3 ; Liu, Xiaoling 1 ; Karrow, Niel A. 4 ; Wang, Chunfang 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Freshwater Aquaculture Collaborat Innovat Ctr Hub, Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Peoples R China

2.Albert Einstein Coll Med, Dept Genet, 1301 Morris Pk Ave, Bronx, NY 10461 USA

3.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

4.Univ Guelph, Dept Anim Biosci, Guelph, ON N1G 2W1, Canada

关键词： Yellow catfish; Vitamin D-3; Edwardsiella ictaluri; Next-generation sequencing; Immunomodulatory

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

ISSN： 1050-4648

年卷期： 2020 年 99 卷

页码：

收录情况： SCI

摘要： Edwardsiella ictaluri (E. ictaluri) causes severe infections in yellow catfish (Pelteobagrus fulvidraco), which leads to a massive loss in the aquaculture industry especially in catfish commercial production. Previous studies have confirmed that vitamin D-3 is essential in immune regulation in mammals. Based on next-generation sequencing, this study explored the immunomodulatory effects of dietary vitamin D-3 on the head kidney of yellow catfish after E. ictaluri challenge. Current results showed that increasing the content of dietary vitamin D-3 within the experimental concentration range (1120IU/kg-16600IU/kg) could reduce the mortality of the yellow catfish after E. ictaluri challenge. Results of the next-generation sequencing showed that dietary vitamin D-3 regulates the immune mechanism of the head kidney mainly through three pathways i.e. negative regulation of interferon-beta production, negative regulation of interleukin-6 production and neutrophil chemotaxis. Proteins HSPA8, MAP4K4 and MRC1 may be involved in vitamin D-3-mediated immunoregulation in the head kidney. qPCR results showed that increasing the content of dietary vitamin D-3 can improve the immune function of the yellow catfish by down-regulating ifn beta and pro-inflammatory factors tnf-alpha, il1-beta, il-6, il-8 and up-regulating the anti-inflammatory factor il-10. The above results indicated that dietary addition of vitamin D-3 regulated the immune response in head kidney of yellow catfish and helped the fish to resist the negative effects of infection by E. ictaluri in a dose-dependent manner.

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