Preparation and evaluation of danofloxacin mesylate microspheres and its pharmacokinetics in pigs
文献类型： 外文期刊
作者： Wang, Chunmei 1 ; Ai, Diyun 2 ; Chen, Cuilan 1 ; Lin, Heng 1 ; Li, Jing 1 ; Shen, Hongchun 1 ; Yi, Weixue 1 ; Qi, Yuanhua 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Vet Med, Lab Vet Pharmacol & Toxicol, Wuhan 430070, Peoples R China
2.Hubei Acad Agr Sci, Inst Anim Sci & Vet Med, Wuhan 430070, Peoples R China
关键词： swine;pharmacokinetics;drug evaluation;particle size;crosslinking;quinolones;emulsions;in vitro studies;intramuscular injection;lungs;half life
期刊名称：VETERINARY RESEARCH COMMUNICATIONS （ 影响因子：2.459； 五年影响因子：2.352 ）
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收录情况： SCI
摘要： Danofloxacin mesylate gelatin microspheres (DFM-GMS) were prepared by an emulsion chemical crosslinking technique. Distribution of particle size, morphologic characteristics, drug content, and drug stability were evaluated. In-vitro study showed that the release of danofloxacin mesylate (DFM) from microspheres was much slower than from the raw material (DFM) in the release medium. Pharmacokinetic characteristics were evaluated following intramuscular injection of DFM-GMS or DFM in pigs at dosage of 2.5 mg/kg body weight. Elimination half-life (t/o) of the drug was 24.32 h for DFM-GMS, and 6.61 h for DFM (P<0.01). Overall, DFM-GMS could be applied as a long-acting and lung targeting dosage form of DFM for clinical application.
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