Emergence of a Recombinant Bovine Enterovirus in China: Insights from Phylogenetic and Temporal Analysis
文献类型： 外文期刊
作者： Feng, Guidan 1 ; Kang, Taisheng 1 ; Tang, Pan 2 ; Xie, Caihua 3 ; Yan, Ruoqian 3 ; Qian, Weidong 4 ;
作者机构： 1.Shanghai Anim Dis Prevent & Control Ctr, Shanghai 201103, Peoples R China
2.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Med, Shanghai 201106, Peoples R China
3.Henan Ctr Anim Dis Control & Prevent, Zhengzhou 450008, Peoples R China
4.Shaanxi Univ Sci & Technol, Sch Biol & Pharmaceut Sci, Xian 710021, Peoples R China
关键词： bovine enterovirus; diarrhea; molecular characterization; divergence dating; recombination breakpoints
期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 2076-2615
年卷期： 2025 年 15 卷 10 期
页码：
收录情况： SCI
摘要： Bovine enteroviruses (BEVs) are emerging pathogens with poorly understood evolutionary dynamics and zoonotic potential. Here, we report the discovery of a novel recombinant BEV strain, HeN-2022, isolated from cattle in China. Genomic analysis revealed that HeN-2022 is a primary hybrid of BEV-E1 (VG527, Ireland) and BEV-E4 (GX1901, China), with recombination breakpoints in the VP1 gene and 5 ' UTR. Divergence dating traced its origin to 1991, predating closely related strains. Experimental infection in sheep demonstrated asymptomatic viral shedding (peak at 5 dpi) and robust neutralizing antibody responses, highlighting the potential cross-species adaptability. These findings underscore recombination as a potential key driver of BEV evolution and emphasize the need for global surveillance to address emerging livestock pathogens.
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