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Integrated analysis of transcriptome and metabolome reveals the regulatory mechanism of largemouth bass (Micropterus salmoides) in response to Nocardia seriolae infection

文献类型： 外文期刊

作者： Dong, Fen 1 ; Sun, Yu-Long 1 ; Qian, Yuan-Xin 1 ; Chen, Qiang 1 ; He, Jia-Le 1 ; Wang, Ji-Teng 1 ; Han, Tao 1 ; Zhang, Xiu-Mei 1 ; Deng, Yu-Ting 2 ;

作者机构： 1.Zhejiang Ocean Univ, Sch Fisheries, Zhoushan 316022, Peoples R China

2.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev ,Guangdong Prov Key Lab A, Guangzhou 510380, Peoples R China

关键词： Micropterus salmoides; Transcriptome and metabolome studies; Nocardia seriolae; Immune response; Metabolic regulation

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2024 年 145 卷

页码：

收录情况： SCI

摘要： Nocardia seriolae is a severe bacterial pathogen that has seriously affected the development of aquaculture industry. Largemouth bass (Micropterus salmoides) is a commercially significant freshwater fish that suffers a variety of environmental threats, including bacterial pathogens. However, the immune responses and metabolic alterations of largemouth bass to N. seriolae infection remain largely unclear. We discovered that N. seriolae caused pathological alterations in largemouth bass and shifted the transcript of immune-related and apoptotic genes in head kidney after infection. To answer the aforementioned question, a combined transcriptome and metabolome analysis was employed to explore the alterations in genes, metabolites, and metabolic pathways in largemouth bass following bacterial infection. A total of 3579 genes and 1929 metabolites are significant differentially changed in the head kidney post infection. In response to N. seriolae infection, host modifies the PI3K-Akt signaling pathway, TCA cycle, glycolysis, and amino acid metabolism. The integrated analysis of transcriptome and metabolome suggested that with the arginine metabolism pathway as the core, multiple biomarkers (arg gene, arginine) are involved in the antibacterial and immune functions of largemouth bass. Thus, we hypothesized that arginine plays a crucial role in the immune responses of largemouth bass against N. seriolae infection, and increasing arginine levels suitably is beneficial for the host against bacterial infection. Our results shed light on the regulatory mechanism of largemouth bass resistance to N. seriolae infection and contributed to the development of more effective N. seriolae resistance strategies.

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