Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp
文献类型： 外文期刊
作者： Wang, Xin-Xin 1 ; Ding, Ming-Jie 1 ; Gao, Jie 1 ; Zhao, Ling 4 ; Cao, Rong 4 ; Wang, Xian-Wei 1 ;
作者机构： 1.Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cells & Dev Biol, Qingdao, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Peoples R China
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Dept Food Engn & Nutr, Qingdao, Peoples R China
期刊名称：PLOS PATHOGENS （ 影响因子：4.9； 五年影响因子：5.4 ）
ISSN： 1553-7366
年卷期： 2024 年 20 卷 5 期
页码：
收录情况： SCI
摘要： The arthropod exoskeleton provides protection and support and is vital for survival and adaption. The integrity and mechanical properties of the exoskeleton are often impaired after pathogenic infection; however, the detailed mechanism by which infection affects the exoskeleton remains largely unknown. Here, we report that the damage to the shrimp exoskeleton is caused by modulation of host lipid profiles after infection with white spot syndrome virus (WSSV). WSSV infection disrupts the mechanical performance of the exoskeleton by inducing the expression of a chitinase (Chi2) in the sub-cuticle epidermis and decreasing the cuticle chitin content. The induction of Chi2 expression is mediated by a nuclear receptor that can be activated by certain enriched long-chain saturated fatty acids after infection. The damage to the exoskeleton, an aftereffect of the induction of host lipogenesis by WSSV, significantly impairs the motor ability of shrimp. Blocking the WSSV-caused lipogenesis restored the mechanical performance of the cuticle and improved the motor ability of infected shrimp. Therefore, this study reveals a mechanism by which WSSV infection modulates shrimp internal metabolism resulting in phenotypic impairment, and provides new insights into the interactions between the arthropod host and virus.
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