文献类型： 外文期刊
作者： Jiang, Wenyan 1 ; Chen, Xuechai 1 ; Ji, Cuicui 1 ; Zhang, Wenting 1 ; Song, Jianing 1 ; Li, Jie 2 ; Wang, Juan 1 ;
作者机构： 1.Beijing Univ Technol, Ctr Excellence Environm Safety & Biol Effects, Fac Environm & Life Sci, Beijing Int Sci & Technol Cooperat Base Antiviral, 100 Ping Le Yuan, Beijing 100124, Peoples R China
2.Chinese Acad Fishery Sci, Lab Marine Fisheries & Aquaculture, Qingdao Natl Lab Marine Sci & Technol,Yellow Sea, Key Lab Maricultural Organism Dis Control,Minist, Qingdao 266071, Peoples R China
关键词： autophagy; autophagosome; closure; isolation membrane
期刊名称：CELLS （ 影响因子：6.6； 五年影响因子：6.663 ）
ISSN：
年卷期： 2021 年 10 卷 11 期
页码：
收录情况： SCI
摘要： Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.
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