Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem
文献类型： 外文期刊
作者： Sun, Jian 1 ; He, Lili 1 ; Gao, Yuanyu 1 ; Zhai, Lijuan 1 ; Ji, Jingwen 1 ; Liu, Yuanbai 1 ; Ji, Jinbo 1 ; Ma, Xueqin 2 ; Mu 1 ;
作者机构： 1.Ningxia Acad Agr & Forestry Sci, Ningxia Ctr Organ Synth & Engn Technol, Yinchuan 750002, Ningxia, Peoples R China
2.Ningxia Med Univ, Coll Pharm, Yinchuan 750004, Ningxia, Peoples R China
关键词： avibactam; beta-lactams; synergistic effect; amidation; amidines; 1, 6-diazabicyclo[3.2.1]octan-7-ones; sulfates
期刊名称：MENDELEEV COMMUNICATIONS （ 影响因子：1.786； 五年影响因子：1.517 ）
ISSN： 0959-9436
年卷期： 2021 年 31 卷 4 期
页码：
收录情况： SCI
摘要： New avibactam derivatives in which amide moiety is replaced by substituted amidine groupings were obtained in several steps, the key step having involved the conversion of 2-positioned cyano group of the 1,6-diazabicyclo[3.2.1]-octane framework into the amidine one. Synergistic antibacterial activity of the new compounds in combination with meropenem infers the agonistic effect of these derivatives against beta-lactamases.
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