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Protoilludene and Alkenoic Acid Derivatives from the European Polypore Fomitiporia hartigii

文献类型： 外文期刊

作者： Sum, Winnie Chemutai 1 ; Ebada, Sherif S. 1 ; Wang, Hao 3 ; Kellner, Harald 4 ; Stadler, Marc 1 ;

作者机构： 1.Helmholtz Ctr Infect Res GmbH HZI, Dept Microbial Drugs, D-38124 Braunschweig, Germany

2.Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, D-38106 Braunschweig, Germany

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol 1, Key Lab Nat Prod Res & Dev Li Folk Med Hainan Prov, Haikou 571101, Hainan, Peoples R China

4.Tech Univ Dresden, Int Inst Zittau, Dept Bio & Environm Sci, D-02763 Zittau, Germany

5.Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11566, Egypt

期刊名称：ACS OMEGA （ 影响因子：3.7； 五年影响因子：4.0 ）

ISSN： 2470-1343

年卷期： 2024 年 9 卷 28 期

页码：

收录情况： SCI

摘要： Chemical investigation of the solid-state rice culture of the endangered European polypore Fomitiporia hartigii (Hymenochaetaceae) afforded a previously undescribed protoilludene derivative (1) in addition to six known compounds (2-7). Chemical structures of the isolated compounds were established based on HR-ESI-MS, comprehensive 1D/2D NMR spectroscopic analyses, and comparisons with the literature. All isolated compounds were assessed for their cytotoxic and antimicrobial activities. Among the tested compounds, hymeglusin (3) revealed potent cytotoxic activity against all tested cell lines with IC50 values between 0.3 and 6.8 mu M. Compound 3 and fusaridioic acid A (4) revealed weak to moderate antimicrobial activities with its most potent effect against Candida albicans (minimum inhibitory concentration of 4.2 mu g/mL).

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