文献类型： 外文期刊
作者： Goraya, Mohsan Ullah 1 ; Ziaghum, Fozia 3 ; Chen, Shilong 4 ; Raza, Ali 5 ; Chen, Ye 1 ; Chi, Xiaojuan 1 ;
作者机构： 1.Fujian Agr & Forestry Univ, Anim Sci Coll, Key Lab Fujian Taiwan Anim Pathogen Biol, Fuzhou 350002, Fujian, Peoples R China
2.Fujian Agr & Forestry Univ, Life Sci Coll, Fuzhou 350002, Fujian, Peoples R China
3.Bahauddin Zakariya Univ, Dept Pharm, Multan, Pakistan
4.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350002, Fujian, Peoples R China
5.Univ Queensland, Queensland Alliance Agr & Food Innovat, Brisbane, Qld 4072, Australia
关键词： Classical swine fever virus; Pathogenesis; Innate immunity; Immune evasion; Cellular immunity
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）
ISSN： 0882-4010
年卷期： 2018 年 119 卷
页码：
收录情况： SCI
摘要： Classical swine fever virus (CSFV) infection causes mild to severe diseases among pigs, depending on the age and immune status of the host and viral strains. CSFV targets various cells, including macrophages and conventional and plasmacytoid dendritic cells. Classical swine fever is one of the most devastating diseases of pigs which leads to high morbidity and mortality, and causes significant economic loss worldwide. In response to infection with CSFV, host innate immune system eliminates the virus by recognizing specific viral molecules via distinct cellular pattern recognition receptors. These receptors trigger downstream intracellular signaling pathways, which regulate the translocation and activation of transcription factors that control the production of cytokines and interferons (IFNs). In turn, these IFNs activate JAK-STAT signaling that governs the transcription of IFN-stimulated genes (ISGs) that play critical roles in antiviral immunity. However, CSFV has evolved different strategies to evade innate immune signaling and can establish persistent infection without being recognized by immune surveillance. In this review, we discuss the current understanding of host innate response to CSFV infection. We also summarize how CSFV evades innate immunity to establish its chronic infection.
- 相关文献
作者其他论文 更多>>
-
Identification and Genome Characterization of a Novel Muscovy Duck-Origin Goose Parvovirus with Three Recombinant Regions between Muscovy Duck Parvovirus and Goose Parvovirus
作者：Liu, Hongwei;Xu, Zhuoran;Wang, Shao;Cheng, Xiaoxia;Xiao, Shifeng;Zhu, Xiaoli;Zheng, Min;Lin, Fengqiang;Dong, Hui;Jiang, Dandan;Chen, Shaoying;Chen, Shilong;Liu, Hongwei;Xu, Zhuoran;Wang, Shao;Cheng, Xiaoxia;Xiao, Shifeng;Zhu, Xiaoli;Zheng, Min;Lin, Fengqiang;Dong, Hui;Jiang, Dandan;Chen, Shaoying;Chen, Shilong
关键词：
-
Development and application of a multiplex PCR method for the simultaneous detection of goose parvovirus, waterfowl reovirus, and goose astrovirus in Muscovy ducks
作者：Zhang, Shizhong;Dong, Hui;Lin, Fengqiang;Cheng, Xiaoxia;Zhu, Xiaoli;Jiang, Dandan;Xiao, Shifeng;Chen, Shaoying;Chen, Shilong;Wang, Shao
关键词：Goose parvovirus; Waterfowl reovirus; Goose astrovirus; Multiplex PCR
-
In-silico identification and characterization of O-methyltransferase gene family in peanut (Arachis hypogaea L.) reveals their putative roles in development and stress tolerance
作者：Cai, Tiecheng;Sharif, Yasir;Yang, Qiang;Chen, Xiangyu;Chen, Yuting;Dang, Hao;Pan, Yijing;Raza, Ali;Zhang, Chong;Chen, Hua;Zhuang, Weijian;Zhuang, Yuhui;Chen, Xiangyu;Chen, Kun;Gao, Meijia
关键词：bioinformatics; environmental stress; functional annotation; gene duplication; micro-RNAs; peanut genomics; phylogenetic tree
-
Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs
作者：Lin, Chang;Zeng, Xiancheng;Lin, Chang;Zheng, Min;Xiao, Shifeng;Wang, Shao;Zhu, Xiaoli;Chen, Xiuqin;Jiang, Dandan;Chen, Shaoying;Chen, Shilong;Chen, Shilong
关键词：duck; innate immunity; cyclic GMP-AMP synthase; antiviral function; interferon-stimulated genes; sgRNA
-
Rapid detection of H146-like goose calicivirus using a TaqMan-based real-time PCR assay
作者：Zheng, Min;Lin, Su;Zhang, Shizhong;Chen, Xiuqin;Jiang, Dandan;Chen, Shaoying;Wang, Shao;Chen, Shilong;Zheng, Min;Lin, Su;Zhang, Shizhong;Chen, Xiuqin;Chen, Shaoying;Wang, Shao;Chen, Shilong
关键词：goose calicivirus; H146-like; real-time PCR; TaqMan probe; virus detection
-
Duckling short beak and dwarfism syndrome virus infection activates host innate immune response involving both DNA and RNA sensors
作者：Chen, Shilong;Xiao, Shifeng;Lin, Fengqiang;Cheng, Xiaoxia;Wang, Shao;Zhu, Xiaoli;Chen, Xiuqin;Zheng, Min;Huang, Meiqing;Chen, Shaoying;Chen, Shilong;Chen, Shilong;Fang, Tiehui;Munir, Muhammad;Yu, Fusong
关键词：Duckling short beak and dwarfism syndrome virus (SBDSV); Goose parvovirus; Duck embryo fibroblast; Innate immune response; Pattern recognition receptors
-
Rapid detection of H146-like goose calicivirus using real-time RT-PCR with a Taqman minor groove binder probe
作者：Zheng, Min;Lin, Su;Zhang, Shizhong;Chen, Xiuqin;Jiang, Dandan;Chen, Shaoying;Wang, Shao;Chen, Shilong;Zheng, Min;Lin, Su;Zhang, Shizhong;Chen, Xiuqin;Chen, Shaoying;Wang, Shao;Chen, Shilong
关键词：Goose calicivirus; H146-like; Real-Time RT-PCR; TaqMan-MGB; Probe; Virus detection
