Three unusual hybrid sorbicillinoids with anti-inflammatory activities from the deep-sea derived fungus Penicillium sp. SCSIO06868
文献类型： 外文期刊
作者： Pang, Xiaoyan 1 ; Wang, Pei 2 ; Liao, Shengrong 1 ; Zhou, Xuefeng 1 ; Lin, Xiuping 1 ; Yang, Bin 1 ; Tian, Xinpeng 1 ; Wang, Junfeng 1 ; Liu, Yonghong 1 ;
作者机构： 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Innovat Acad South China Sea Ecol & Environm Engn, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Peoples R China
2.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China
3.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China
关键词： Penicillium sp. SCSIO06868; Aspergillaceae; Deep-sea derived fungus; Sorbicillinoids; Anti-inflammatory activities; Molecular networking
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.004； 五年影响因子：4.129 ）
ISSN： 0031-9422
年卷期： 2022 年 202 卷
页码：
收录情况： SCI
摘要： Under the guidance of MS/MS based molecular networking, bisorbicillchaetones A-C, three undescribed hybrid sorbicillinoids, were isolated from cultures of the deep-sea derived fungus Penicillium sp. SCSIO06868. The planar structures and absolute configurations of these compounds were determined by extensive spectroscopic analyses. Bisorbicillchaetones are the first examples of hybrid sorbicillinoids containing a coniochaetone unit. Bisorbicillchaetones A and B exhibited moderate inhibitory effect on NO production in LPS activated RAW264.7 cells with the IC50 values of 80.3 +/- 3.6 mu M and 38.4 +/- 3.3 mu M, respectively, without cytotoxicity observed.
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