文献类型： 外文期刊
作者： Wang, Pei 1 ; Wang, Huifang 1 ; Yang, Juchun 1 ; Yang, Li 1 ; Cai, Caihong 1 ; Yuan, Jingzhe 1 ; Wu, Fei 1 ; Gai, Cuijuan 1 ; Mei, Wenli 1 ; Dai, Haofu 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
2.Guangxi Minzu Univ, Sch Chem & Chem Engn, Nanning 530000, Peoples R China
关键词： isocoumarins; marine fungus; Phaeosphaeriopsis sp; neuroprotective effect; cytotoxicity
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN：
年卷期： 2023 年 21 卷 3 期
页码：
收录情况： SCI
摘要： Five new isocoumarins, phaeosphaerins A-E (1-5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1-7 displayed weak neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
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