Azaphilone Derivatives from the Fungus Coniella fragariae Inhibit NF-kappa B Activation and Reduce Tumor Cell Migration
文献类型： 外文期刊
作者： Yu, Haiqian 1 ; Sperlich, Julia 2 ; Mandi, Attila 3 ; Kurtan, Tibor 3 ; Dai, Haofu 4 ; Teusch, Nicole 2 ; Guo, Zhi-Yon 1 ;
作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany
2.TH Koln, Fac Appl Nat Sci, Biopharmaceut Chem & Mol Pharmacol, Chempark, D-51368 Leverkusen, Germany
3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary
4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
5.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
6.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yi
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）
ISSN： 0163-3864
年卷期： 2018 年 81 卷 11 期
页码：
收录情况： SCI
摘要： Seven new azaphilones, coniellins A-G (1-7), were obtained from the fungus Coniella fragariae that had been isolated from goose dung. Their structures were elucidated by analysis of 1D and 2D NMR as well as HRESIMS data. TDDFT-ECD calculation was used to determine the absolute configuration of 1, while Mosher's method was applied to determine the absolute configuration of 5. While displaying only moderate cytotoxicity, compound 1 exhibited significant inhibition of NF-kappa B activation in the triple negative breast cancer cell line MDA-MB-231 with an IC50 value of 4.4 mu M. Moreover, compounds 1, 4, and 5 clearly reduced tumor cell migration. Compound 1 was the most active derivative tested in this assay and displayed 60% inhibition of tumor cell migration at a dose of 5 mu M and 98% inhibition at 10 mu M after 24 h.
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