Two unprecedented 2-(2-phenethyl)chromone derivatives with anti-Helicobacter pylori and anti-inflammatory activities from agarwood of Aquilaria crassna
文献类型： 外文期刊
作者： Li, Xiao-Hong 1 ; Wang, Hao 2 ; Mei, Wen-Li 2 ; Dong, Wen-Hua 2 ; Zeng, Jun 2 ; Huang, Sheng-Zhuo 2 ; Chen, Hui-Qin 2 ; Wei, Yan-Mei 2 ; Wu, Fei 2 ; Guo, Zhi-Yong 1 ; Dai, Hao-Fu 2 ;
作者机构： 1.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Natl Key Lab Trop Crop Breeding,Int Joint Res Ctr, Haikou 571101, Peoples R China
关键词： Aquilaria crassna; Agarwood; 2-(2-Phenylethyl)chromone; Anti-Helicobacter pylori activity; Anti-inflammatory activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.4； 五年影响因子：1.5 ）
ISSN： 1874-3900
年卷期： 2025 年 69 卷
页码：
收录情况： SCI
摘要： Two unprecedented 2-(2-phenethyl)chromone derivatives, 4 '-demethoxy-aquisinenin I (1) and 6"-methoxycrassna B (2),together with a known 2-(2-phenylethyl)chromone dimer (3), were isolated from the ethanol extract of agarwood of Aquilaria crassna. Their structures were constructed through comprehensive spectroscopic analysis, including 1D and 2D NMR, HRESIMS. All compounds were screened for their anti-Helicobacter pylori activity and ability to inhibit nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Compound 1 exhibited anti-Helicobacter pylori effect with a MIC value of 40 mu M, and anti-inflammatory activity with an IC50 value of 14.10 +/- 1.04 mu M.
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