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Six New Phragmalin Limonoids from the Stems of Chukrasia tabularis A. Juss

文献类型: 外文期刊

作者: Wang, Yan-Cui 1 ; Kong, Fan-Dong 1 ; Wang, Hao 1 ; Mei, Wen-Li 1 ; Liu, Shou-Bai 2 ; Zhao, You-Xing 1 ; Dai, Hao-Fu 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

2.Hainan Univ, Inst Trop Agr & Forestry, Haikou 570228, Hainan, Peoples R China

关键词: Chukrasia tabularis A; Juss; Meliaceae; phragmalin limonoid; -glucosidase inhibition activity; acetylcholinesterase inhibitory activity

期刊名称:MOLECULES ( 影响因子:4.411; 五年影响因子:4.587 )

ISSN: 1420-3049

年卷期: 2018 年 23 卷 11 期

页码:

收录情况: SCI

摘要: Six new phragmalin limonoids, named moluccensin Z1 (1), moluccensin Z2 (2), carapanolide Y (3), tabulalin N (4), chukvelutilide A1 (5), and velutinasin J (6), as well as two known compounds, chukvelutilide A (7) and velutinasin D (8) were isolated from the stems of Chukrasia tabularis A. Juss. The structures of the new compounds 1-6 were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for -glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against -glucosidase and acetylcholinesterase in vitro.

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