您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Stabilization of Liposomes by Perfluorinated Compounds

文献类型： 外文期刊

作者： Wang, Heye 1 ; Zhang, Xiaohan 3 ; Liu, Yibo 3 ; Liu, Juewen 3 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Jiangsu Key Lab Food Qual, Nanjing 210014, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Safety State Key Lab Cultivat Base MOST, Nanjing 210014, Jiangsu, Peoples R China

3.Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem, Waterloo, ON N2L 3G1, Canada

期刊名称：ACS OMEGA （ 影响因子：3.512； 五年影响因子：3.613 ）

ISSN： 2470-1343

年卷期： 2018 年 3 卷 11 期

页码：

收录情况： SCI

摘要： Perfluorinated compounds (PFCs) are emerging persistent environmental contaminants that may be toxic to animals and humans. To gain fundamental insights into the mechanism of their toxicity, the interactions of phosphocholine (PC) liposomes as model membranes were studied with three types of PFCs, including perfluorooctanoic acid, perfluorooctane sulfonate, and perfluorohexanesulfonic acid potassium salt, together with three common surfactants: sodium dodecyl sulfate (SDS), cetyltrimethylammonium bromide (CTAB), and sodium 1-heptanesulfonate (SHS). The interactions were systematically characterized by zeta potential measurement, dynamic light scattering, negative-stain transmission electron microscopy, and fluorescence spectroscopy. Unmodified liposomes, calcein-loaded liposomes, and Laurdan dye-embedded liposomes were all tested. By gradually increasing the temperature, the three PFCs and SHS decreased the leakage of calcein-loaded 1,2-dipalmitoyl-sn-glycero-3-phosphocholine liposomes, whereas SDS and CTAB increased the leakage. The PFCs that affected the lipid membranes stronger than SHS were attributable to their perfluoroalkyl carbon chains. Packing of the lipids was further studied using Laurdan dye as a probe. Calcein leakage tests also indicated that PFCs inhibited lipid membrane leakage induced by inorganic nanoparticles such as silica and gold nanoparticles. This study confirmed the similar effect of the PFCs as cholesterol in affecting membrane properties and would be helpful for understanding the interaction mechanism of PFCs and cell membranes.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台