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Virulence Gene Distribution of Salmonella Pullorum Isolates Recovered from Chickens in China (1953-2015)

文献类型： 外文期刊

作者： Zhang, Di 1 ; Zhuang, Linlin 3 ; Wang, Chengming 4 ; Zhang, Ping 1 ; Zhang, Tengfei 5 ; Shao, Huabin 5 ; Han, Xiangan; 1 ;

作者机构： 1.Chinese Acad Agr Sci, Poultry Inst, Yangzhou 225125, Jiangsu, Peoples R China

2.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225002, Jiangsu, Peoples R China

3.Southeast Univ, Sch Biol Sci & Med Engn, Jiangsu Key Lab Biomat & Devices, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

4.Auburn Univ, Dept Pathobiol, Coll Vet Med, Auburn, AL 36849 USA

5.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Key Lab Prevent & Control Agents Anim Bacteriosis, Wuhan 430064, Hubei, Peoples R China

6.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

关键词： Salmonella enterica; Gallinarum; Pullorum; virulence genotype; pathogenicity islands; China

期刊名称：AVIAN DISEASES （ 影响因子：1.577； 五年影响因子：1.915 ）

ISSN： 0005-2086

年卷期： 2018 年 62 卷 4 期

页码：

收录情况： SCI

摘要： Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (Salmonella Pullorum) has strict host specificity for poultry, and pullorum disease seriously threatens the poultry industry. Virulence genes play a central role in Salmonella pathogenicity, but very few reports are available on the distribution of virulence genes in Salmonella Pullorum. In this study, we investigated 304 Salmonella Pullonun isolates recovered from chickens in China between 1953 and 2015 for the presence of 25 Salmonella virulence genes (invA, orgA, prgH, sitC, spaN, sifA, spiA, ttrC, mgtB, misL, siiE spi4D, pipA, sipB, sopB, sefA, cdtB, pagC, shdA, msgA, lpfC, tolC, iroN, pefA, and spvB), including pathogenicity island genes, fimbriae genes, and virulence plasmid genes. PCR showed that 15 of the 25 virulence genes were present in all isolates tested, whereas cdtB was not present in any isolate. The presence rates of the remaining genes ranged from 97.7% to 99.7%. The variation rates of these virulence genes was low, and no significant differences were identified in the distribution of virulence genes over time. On the basis of the distribution of these virulence genes, the 304 Salmonella Pullorum isolates were divided into 10 virulence genotypes. The major genotype, which comprised 93.4% of all isolates, included isolates that carried 24 of the virulence genes assessed. The results of this study will help in the characterization of Salmonella Pullorum and in the study of the correlation between virulence genotypes and pathogenicity.

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