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Three New 2-(2-Phenylethyl)chromone Derivatives of Agarwood Originated from Gyrinops salicifolia

文献类型： 外文期刊

作者： Dong, Wen-Hua 1 ; Wang, Hao 2 ; Guo, Feng-Juan 2 ; Mei, Wen-Li 2 ; Chen, Hui-Qin 2 ; Kong, Fan-Dong 3 ; Li, Wei; Zhou, 1 ;

作者机构： 1.Hainan Univ, Inst Trop Agr & Forestry, Haikou 570228, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources

关键词： agarwood; Gyrinops salicifolia; 2-(2-phenylethyl)chromone; acetylcholinesterase inhibitory; cytotoxicity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2019 年 24 卷 3 期

页码：

收录情况： SCI

摘要： Two new 2-(2-phenylethyl)chromone derivatives (1-2), comprising 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and benzylacetone moieties, together with one new 2-(2-phenylethenyl)chromone (3) were isolated from the ethyl acetate extraction of agarwood originated from Gyrinops salicifolia Ridl. All structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. All isolated compounds were tested for acetylcholinesterase (AChE) inhibitory activity and cytotoxic activity against human myeloid leukemia cell line (K562). However, none of the compounds displayed AChE inhibitory activity at a concentration of 50 mu g mL(-1) or cytotoxic activity against K562 cell line.

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