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Transcriptome Analysis Reveals the Molecular Mechanism of Resting Cyst Formation in Colpoda aspera

文献类型： 外文期刊

作者： Jiang, Chuanqi 1 ; Wei, Wei 1 ; Yan, Guanxiong 1 ; Shi, Tuanyuan 3 ; Miao, Wei 1 ;

作者机构： 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, 7 South Donghu Rd, Wuhan 430072, Hubei, Peoples R China

2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Med, Dept Anim Parasitol, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Ciliate; encystment; transcriptome sequencing

期刊名称：JOURNAL OF EUKARYOTIC MICROBIOLOGY （ 影响因子：3.346； 五年影响因子：2.809 ）

ISSN： 1066-5234

年卷期： 2019 年 66 卷 2 期

页码：

收录情况： SCI

摘要： Resting cyst formation is a remarkable survival strategy used by ciliates in response to the adverse environmental conditions. However, the mechanisms underlying encystment are poorly understood. Here, the genetic basis of encystment in Colpoda aspera was examined through RNA sequencing to identify transcriptome-wide changes in gene expression between vegetative and encystment stages. After de novo assembly, 49,543 transcripts were identified. Gene annotation and pathway mapping analysis revealed marked changes in biosynthesis, energy metabolism, and autophagy pathways during cyst formation. In addition, some differentially regulated genes were predicted to function in the interconnected cAMP, AMPK, mTOR, and PI3K/AKT signaling pathways, potentially forming a regulatory network for encystment. The present study conducted a large-scale assessment of Colpoda aspera genomic resources and provides new insight into the molecular mechanisms underlying cyst formation.

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