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The bovine herpesvirus 1 regulatory proteins, bICP4 and bICP22, are expressed during the escape from latency

文献类型： 外文期刊

作者： Guo, Junqing 1 ; Li, Qingmei 1 ; Jones, Clinton 2 ;

作者机构： 1.Henan Acad Agr Sci, Key Lab Anim Immunol, 116 Huayuan Rd, Zhengzhou, Henan, Peoples R China

2.Oklahoma State Univ, Dept Vet Pathobiol, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA

关键词： Bovine herpesvirus 1; Stress-induced reactivation from latency; ICP4; ICP22

期刊名称：JOURNAL OF NEUROVIROLOGY （ 影响因子：2.643； 五年影响因子：2.987 ）

ISSN： 1355-0284

年卷期： 2019 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Following acute infection of mucosal surfaces by bovine herpesvirus 1 (BoHV-1), sensory neurons are a primary site for lifelong latency. Stress, as mimicked by the synthetic corticosteroid dexamethasone, consistently induces reactivation from latency. Two viral regulatory proteins (VP16 and bICP0) are expressed within 1h after calves latently infected with BoHV-1 are treated with dexamethasone. Since the immediate early transcription unit 1 (IEtu1) promoter regulates both BoHV-1 infected cell protein 0 (bICP0) and bICP4 expressions, we hypothesized that the bICP4 protein is also expressed during early stages of reactivation from latency. In this study, we tested whether bICP4 and bICP22, the only other BoHV-1 protein known to be encoded by an immediate early gene, were expressed during reactivation from latency by generating peptide-specific antiserum to each protein. bICP4 and bICP22 protein expression were detected in trigeminal ganglionic (TG) neurons during early phases of dexamethasone-induced reactivation from latency, operationally defined as the escape from latency. Conversely, bICP4 and bICP22 were not readily detected in TG neurons of latently infected calves. In summary, it seems clear that all proteins encoded by known BoHV-1 IE genes (bICP4, bICP22, and bICP0) were expressed during early stages of dexamethasone-induced reactivation from latency.

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