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Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2

文献类型： 外文期刊

作者： Gan, Mailin 1 ; Zheng, Ting 1 ; Shen, Linyuan 1 ; Tan, Ya 1 ; Fan, Yuan 1 ; Shuai, Surong 1 ; Bai, Lin 1 ; Li, Xuewei 1 ; Wa 1 ;

作者机构： 1.Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Sichuan, Peoples R China

2.Guizhou Acad Agr Sci, Inst Anim Husb & Vet, Guiyang 550005, Guizhou, Peoples R China

3.Chongqing Acad Anim Sci, Rongchang 402460, Peoples R China

关键词： Genistein; miR-451; TIMP2; Isoproterenol; Cardiac hypertrophy

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：6.529； 五年影响因子：5.979 ）

ISSN： 0753-3322

年卷期： 2019 年 112 卷

页码：

收录情况： SCI

摘要： Cardiomyocyte hypertrophy, a prevalent clinical condition is deeply associated with many physiological factors. The underlying mechanisms of cardiomyocyte hypertrophy are not yet fully understood. In this study, H9C2 cells were treated with genistein, miR-451 mimic, miR-451 inhibitor and isoproterenol for 24 h, to study the effect of genistein on isoproterenol-induced myocardial hypertrophy in vitro. Simultaneously, ICR mice were treated with genistein for 21 days to evaluate the effects of the phytochemical on isoproterenol-induced myocardial hypertrophy in vivo. Results showed that isoproterenol induced cardiac hypertrophy and down-regulated the expression of miR-451 and up-regulated miR-451's target gene TIMP2. Genistein increased the expression of miR-451 and inhibited the isoproterenol-induced cardiac hypertrophy. This study explored the function of genistein from the epigenetic level, suggesting that miR-451 may play a significant role in the genistein-assisted amelioration of isoproterenol-induced cardiac hypertrophy both in vitro and in vivo.

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