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Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

文献类型： 外文期刊

作者： Zhang, Renshuai 1 ; Qin, Xiaofei 1 ; Kong, Fandong 3 ; Chen, Pengwei 3 ; Pan, Guojun 4 ;

作者机构： 1.Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Flexible Elect, Nanjing 211800, Jiangsu, Peoples R China

2.Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat, Nanjing 211800, Jiangsu, Peoples R China

3.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou, Hainan, Peoples R China

4.Taishan Med Univ, Sch Life Sci, Tai An 271000, Shandong, Peoples R China

关键词： Cellular uptake; delivery systems; plasma membrane; pro-drugs; disulfide exchange

期刊名称：DRUG DELIVERY （ 影响因子：6.419； 五年影响因子：6.169 ）

ISSN： 1071-7544

年卷期： 2019 年 26 卷 1 期

页码：

收录情况： SCI

摘要： Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. The cellular uptake of macromolecules and drug carriers is very inefficient without external assistance. Therefore, it is desirable to develop potent delivery systems for achieving effective intracellular delivery of chemic entities. Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular uptake is affected by the interaction between the chemical entity and the plasma membrane. In this review, we aimed to develop a profound understanding of the interactions between delivery systems and components of the plasma membrane. For the purpose, we attempt to present a broad overview of what delivery systems can be used to enhance the intracellular delivery of poorly permeable chemic entities, and how various delivery strategies are applied according to the components of plasma membrane.

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