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Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field

文献类型： 外文期刊

作者： Lin, Xiuping 1 ; Li, Kunlong 1 ; Yang, Lilin 1 ; Peng, Xiaoying 1 ; Fang, Wei 3 ; Tian, Xinpeng 1 ; Liu, Yonghong 1 ; Zho 1 ;

作者机构： 1.Chinese Acad Sci, Guangdong Key Lab Marine Materia Med, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou, Guangdong, Peoples R China

2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing, Peoples R China

3.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan, Hubei, Peoples R China

4.Guangzhou 6 Middle Sch, Guangzhou, Guangdong, Peoples R China

5.Shenzhen Univ, Shenzhen, Peoples R China

关键词： Hydrothermal bacteria; dereplication; targeted isolation; antivirus; butyrolactone I 3-sulphate

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期： 2019 年 33 卷 4 期

页码：

收录情况： SCI

摘要： Marine micro-organisms in the deep-sea hydrothermal vent systems are considered as potential sources of bioactive natural products. Sixteen bacterial strains were isolated from a deep-sea hydrothermal field and screened for bioactive metabolism studies. After the strains were subjected to bioactive testing at different culture media, chemical dereplication by HPLC coupled to high-resolution mass spectrometer was performed to analyse or determine the main secondary metabolisms in those strains. Strain 06204 was large-scale fermented with relative optimal media, for isolating the desired sulphur compound. Butyrolactone I 3-sulphate was isolated and structurally identified from the extract, guided by dereplication and showed moderate antivirus activities against H3N2 and EV71 viruses. Our study suggests that deep-sea hydrothermal bacteria are good sources of sulphur natural products. Meanwhile, the described approach, mainly bioactive screening, dereplication and targeted isolation, is effective and efficient to discover interesting bioactive compounds in hydrothermal bacteria. [GRAPHICS] .

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