文献类型： 外文期刊
作者： Jiang, Sai 1 ; Wan, Ke 1 ; Lou, Hua-Yong 1 ; Yi, Ping 1 ; Zhang, Ni 1 ; Zhou, Mei 1 ; Song, Zhi-Qin 2 ; Wang, Wei 3 ; Wu, Mi 1 ;
作者机构： 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China
2.Guizhou Acad Agr Sci, Inst Modern Chinese Herbal, Guiyang 550006, Guizhou, Peoples R China
3.Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China
关键词： Bletilla striata; Orchidaceae; Bibenzyl derivatives; Antibacterial activities; Minimum inhibitory concentration (MIC)
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）
ISSN： 0031-9422
年卷期： 2019 年 162 卷
页码：
收录情况： SCI
摘要： Ten previously undescribed bibenzyl derivatives (bletistrins A-J), including 5 that have hydroxyl-substituted chiral centres on the aliphatic bibenzyl bridge, along with twelve known bibenzyl derivatives, were isolated from the rhizomes of Bletilla striata. The structures of bletistrins A-J were primarily elucidated on the basis of their 1D and 2D NMR spectroscopic data. The absolute configurations of bletistrins A, D, F, H and I were determined by electronic circular dichroism (ECD) spectroscopic analysis and optical rotation value. Most of the isolated compounds were evaluated for their antibacterial activities against 3 g-positive bacterial strains and 1 g-negative bacterial strain. Bletistrins F, G, and J, bulbocol, shanciguol and shancigusin B showed inhibitory activities, with MICs of (3-28 mu g/mL) against S. aureus ATCC 6538.
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