UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis
文献类型： 外文期刊
作者： Kuang, Tongdong 1 ; Chen, Hui-Qin 1 ; Wang, Hao 1 ; Kong, Fan-Dong 1 ; Cai, Cai-Hong 1 ; Dong, Wen-Hua 1 ; Yuan, Jing- 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN： 2046-2069
年卷期： 2019 年 9 卷 30 期
页码：
收录情况： SCI
摘要： Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A-K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D NMR spectroscopic analysis, and experimental ECD spectra. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity by Ellman's colorimetric method, and compounds 9-11 displayed weak AChE inhibitory activity with the inhibition ranging from 15.6% to 16.8% at a concentration of 50 mu g mL(-1).
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