文献类型： 外文期刊
作者： Ao, Zheng 1 ; Wu, Xiao 1 ; Zhou, Jun 1 ; Gu, Ting 1 ; Wang, Xingwang 1 ; Shi, Junsong 3 ; Zhao, Chengfa 1 ; Cai, Gengyuan 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Guangdong, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Guangdong, Peoples R China
3.Wens Foodstuff Grp Co Ltd, Guangdong Wens Pig Breeding Technol Co Ltd, Yunfu, Guangdong, Peoples R China
关键词： allantoic fluid; cloned; pig fetuses; placenta; SCNT
期刊名称：MOLECULAR REPRODUCTION AND DEVELOPMENT （ 影响因子：2.609； 五年影响因子：3.47 ）
ISSN： 1040-452X
年卷期：
页码：
收录情况： SCI
摘要： Cloned pig fetuses produced by somatic cell nuclear transfer show a high incidence of erroneous development in the uteri of surrogate mothers. The mechanisms underlying the abnormal intrauterine development of cloned pig fetuses are poorly understood. This study aimed to explore the potential causes of the aberrant development of cloned pig fetuses. The levels of numerous fatty acids in allantoic fluid and muscle tissue were lower in cloned pig fetuses than in artificial insemination-generated pig fetuses, thereby suggesting that cloned pig fetuses underwent fatty acid deficiency. Cloned pig fetuses also displayed trophoblast hypoplasia and a reduced expression of placental fatty acid transport protein 4 (FATP4), which is the predominant FATP family member expressed in porcine placentas. This result suggested that the placental fatty acid transport functions were impaired in cloned pig fetuses, possibly causing fatty acid deficiency in cloned pig fetuses. The present study provides useful information in elucidating the mechanisms underlying the abnormal development of cloned pig fetuses.
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