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Gill oxidative damage caused by acute ammonia stress was reduced through the HIF-1 alpha/NF-kappa b signaling pathway in golden pompano (Trachinotus ovatus)

文献类型： 外文期刊

作者： Liu, Ming-Jian 1 ; Guo, Hua-Yang 1 ; Liu, Bo 1 ; Zhu, Ke-Cheng 1 ; Guo, Liang 1 ; Liu, Bao-Suo 1 ; Zhang, Nan 1 ; Yang, J 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Minist Agr & Rural Affairs, Guangzhou 510300, Guangdong, Peoples R China

2.Tianjin Agr Univ, Coll Fisheries, Tianjin 300384, Peoples R China

3.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Guangdong, Peoples R China

4.Guangdong Prov Engineer Technol Res Ctr Marine Bi, Guangzhou 510300, Guangdong, Peoples R China

5.Chinese Acad Fishery Sci, Trop Aquaculture Res & Dev Ctr, South China Sea Fisheries Res Inst, Sanya 572018, Peoples R China

6.Sanya Trop Fisheries Res Inst, Sanya, Hainan, Peoples R China

关键词： Fish; Biochemical parameters; Histological changes; Oxidative stress; Inflammatory response

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2021 年 222 卷

页码：

收录情况： SCI

摘要： This study aimed to investigate the intoxication mechanism of golden pompano (Trachinotus ovatus) exposed to high ammonia levels and the effects on the immune and antioxidant mechanisms of gills. Juvenile golden pompano was exposed to ammonia (total ammonia: 26.9 mg/L) to induce 96 h of ammonia stress, and a 96 h recovery experiment was performed after poisoning. Then, we evaluated hematological parameters, the histological structure and the expression of related genes. In this experiment, continuous exposure to high levels of ammonia led to a significant increase in plasma alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH) levels (P < 0.05), and the levels of triiodothyronine (T3) and tetraiodothyronine (T4) were significantly reduced (P < 0.05). Moreover, the expression of antioxidant genes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) increased (P < 0.05). These results indicate that ammonia activates the active osmotic regulatory mechanism of fish gills and participates in defense and immune responses. However, with prolonged exposure to ammonia, the balance of the defense system is disrupted, leading to oxidative damage and inflammation of the gill tissue. This research not only helps elucidate the intoxication mechanism of golden pompano by ammonia at the molecular level but also provides a theoretical basis for further research on detoxification mechanisms.

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