Preparation of ceftiofur-encapsulated hen-egg low-density lipoproteins and their antibacterial effects on intracellular Staphylococcus aureus
文献类型： 外文期刊
作者： Zhao, Yi 1 ; Mao, Wei 1 ; Liu, Bo 1 ; Wang, Yong-fei 1 ; Zhang, Shuang-yi 1 ; Guo, Li-li 1 ; Qian, Ying-hong 4 ; Gong, Zhi-guo 1 ; Zhao, Jia-min 1 ; Yang, Xiao-lin 1 ; Qu, Gang-gang 1 ; Hasi, Su-rong 1 ; Bai, Yu-ting 1 ; Cao, Jin-shan 1 ;
作者机构： 1.Inner Mongolia Agr Univ, Coll Vet Med, Lab Vet Clin Pharmacol, 29 Erdosdong Rd, Hohhot 010011, Peoples R China
2.Inner Mongolia Agr Univ, Key Lab Clin Diag & Treatment Tech Anim Dis, Minist Agr, 29 Erdosdong Rd, Hohhot 010011, Peoples R China
3.Inner Mongolia Med Univ, Hohhot 010030, Peoples R China
4.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010010, Peoples R China
关键词： Hen-egg low-density lipoprotein; Ceftiofur; Intracellular drug delivery system; Staphylococcus aureus
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2024 年 278 卷
页码：
收录情况： SCI
摘要： Hen egg low-density lipoprotein (heLDL), as alternative of serum-derived LDL, was used as drug delivery system of ceftiofur (CEF). The CEF-loaded hen egg low-density lipoprotein (CEF-heLDL) with complete apolipoprotein structure and high drug loading rate was synthesized, possesses suitable particle size. CEF-heLDL undergoes cellular uptake and colocalizes with lysosomes in vitro. An intracellular infection model of the bovine endometrial epithelial cells and a coeliac-induced inflammation model of mice by Staphylococcus aureus (S. aureus) were established, and significantly lower intracellular S. aureus levels of CEF-heLDL group than CEF-free group (P < 0.001) was observed. The antibacterial efficacy was sustained for 24 h. Up to 400 mg/kg of CEF-heLDL, 20 times the clinical practice, were intraperitoneally administrated, and no significant toxicity signs on mice were observed. HeLDLs is an effective, safe, and cheap drug carrier, and could also be used for transmembrane delivering other antibiotics.
- 相关文献
作者其他论文 更多>>
-
Targeting the mPGES-PGE2-EP4 pathway with MF63, MK886, and Grapiprant as a potential therapeutic strategy for Escherichia coli-induced endometritis in dairy cows
作者：Yang, Xiaolin;Guo, Lili;Gong, Pengfei;Wu, Jingze;Zhang, Shuangyi;Guo, Wenrui;Cao, Jinshan;Feng, Shuang;Mao, Wei;Yang, Xiaolin;Guo, Lili;Gong, Pengfei;Wu, Jingze;Zhang, Shuangyi;Guo, Wenrui;Cao, Jinshan;Feng, Shuang;Mao, Wei;Gong, Pengfei;Qian, Yinghong
关键词：Escherichia coli; Endometritis; Prostaglandin E 2; MF63; MK886; Grapiprant
-
Egg yolk-derived low-density lipoprotein: A potential drug delivery system to eradicate intracellular bacteria
作者：Zhao, Yi;Liu, Bo;Zhang, Shuang-yi;Wang, Yong-fei;Hasi, Su-rong;Gong, Zhi-guo;Zhao, Jia-min;Yang, Xiao-lin;Bai, Yu-ting;Cao, Jin-shan;Mao, Wei;Zhao, Yi;Liu, Bo;Zhang, Shuang-yi;Gong, Zhi-guo;Zhao, Jia-min;Yang, Xiao-lin;Cao, Jin-shan;Mao, Wei;Wang, Yong-fei;Qian, Ying-hong
关键词：Hen egg low-density lipoprotein; Ceftiofur; Intracellular drug delivery system; Staphylococcus aureus
-
Investigating the role of the mPGES-PGE2-EP4 pathway in Escherichia coli-induced mastitis in dairy cows: insights for non-antibiotic therapeutic strategies
作者：Yang, Xiaolin;Li, Xueqiang;Guo, Lili;Gong, Pengfei;Zhang, Shuangyi;Liu, Bo;Guo, Wenrui;Bao, Haixia;Mao, Wei;Yang, Xiaolin;Li, Xueqiang;Guo, Lili;Gong, Pengfei;Zhang, Shuangyi;Liu, Bo;Guo, Wenrui;Bao, Haixia;Mao, Wei;Gong, Pengfei;Qian, Yinghong
关键词：
Escherichia coli ; mastitis; alternative treatments to antibiotics; mPGES-1 inhibitors; EP4 receptor inhibitor -
Regulatory Effect of PGE2-EP2/EP4 Receptor Pathway on Staphylococcus aureus-Induced Inflammatory Factors in Dairy Cow Neutrophils
作者：Zhao, Yi;Wang, Chao;Liu, Bo;Zhang, Shuangyi;Wang, Yongfei;Gong, Zhiguo;Zhao, Jiamin;Yang, Xiaolin;Bai, Yuting;Mao, Wei;Zhao, Yi;Wang, Chao;Liu, Bo;Zhang, Shuangyi;Gong, Zhiguo;Zhao, Jiamin;Yang, Xiaolin;Wang, Yongfei;Qian, Yinghong
关键词：neutrophils of cows; Staphylococcus aureus Rosenbach; prostaglandin E-2; EP2/EP4 receptor pathway; anti-inflammatory therapy
-
The effect of taurochenodeoxycholic acid on the glucocorticoid receptor-mediated PLC-IP3-calcium pathway in synoviocytes derived from a rat adjuvant arthritis model
作者：Guanqia, Sangjide;Li, Peifeng;Cao, Jinshan;Mao, Wei;Wu, Jindi;Guanqia, Sangjide;Li, Peifeng;Cao, Jinshan;Bai, Fan;Qian, Yinghong;Mao, Wei
关键词：taurochenodeoxycholic acid; rat adjuvant arthritis model; glucocorticoid receptor; phospholipase C-inositol trisphosphate-Ca2+ signalling pathway
-
Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis
作者：Liu, Kun;Shen, Yuan;Zhang, Nan;Liu, Kun;Shen, Yuan;Wu, Jindi;Mao, Wei;Cao, Jinshan;Pei, Le;Qian, Yinghong
关键词：Endometritis; S. aureus infection; Prostaglandin E2; Immunology
-
Effect of different genetic backgrounds on rumen microbiota and serum metabolic phenotypes in beef cattle
作者：Zhao, Yaxing;Zhang, Chunhua;Sun, Haizhou;Chen, Hao;Zhao, Pengfei;Wu, Yi;Li, Xiaorui;Huangfu, Mingke;Chen, Zhimeng;Liu, Bo;Simujide, Huasai;Chen, Aorigele;Wang, Chunjie
关键词：Serum biochemical indicators; Rumen SCFAs; Rumen microbiota; 16S rRNA sequencing; Simmental cattle
