文献类型： 外文期刊

作者： El-Shall, Nahed A. ¹ ; Jiang, Shouqun ² ; Farag, Mayada R. ³ ; Azzam, Mahmoud ⁴ ; Al-Abdullatif, Abdulaziz A. ⁴ ; Alhotan, Rashed ⁴ ; Dhama, Kuldeep ⁶ ; Hassan, Faiz-ul ⁷ ; Alagawany, Mahmoud ⁸ ;

作者机构： 1.Alexandria Univ, Fac Vet Med, Dept Poultry & Fish Dis, Edfina, El Beheira, Egypt

2.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangdong Prov Key Lab Anim Breeding & Nutr, Inst Anim Sci,Guangdong Acad Agr Sci,State Key Lab, Guangzhou, Guangdong, Peoples R China

3.Zagazig Univ, Fac Vet Med, Forens Med & Toxicol Dept, Zagazig, Egypt

4.King Saud Univ, Dept Anim Prod, Coll Food & Agr Sci, Riyadh, Saudi Arabia

5.Mansoura Univ, Agr Fac, Poultry Prod Dept, Mansoura, Egypt

6.Indian Vet Res Inst, Indian Council Agr Recearch, Div Pathol, Bareilly, Uttar Pradesh, India

7.Univ Agr Faisalabad, Inst Anim & Dairy Sci, Faisalabad, Pakistan

8.Zagazig Univ, Agr Fac, Poultry Dept, Zagazig, Egypt

关键词： Spirulina platensis; poultry; production; immunity; antimicrobials; antiviral; anticoccidial; nutrition

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.3； 五年影响因子：8.0 ）

ISSN： 1664-3224

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Increase in drug resistance as well as ineffective immunization efforts against various pathogens (viruses, bacteria and fungi) pose a significant threat to the poultry industry. Spirulina is one of the most widely used natural ingredients which is becoming popular as a nutritional supplement in humans, animals, poultry and aquaculture. It contains protein, vitamins, minerals, fatty acids, pigments, and essential amino acids. Moreover, it also has considerable quantities of unique natural antioxidants including polyphenols, carotenoids, and phycocyanin. Dietary supplementation of Spirulina can beneficially affect gut microbial population, serum biochemical parameters, and growth performance of chicken. Additionally, it contains polyphenolic contents having antibacterial effects. Spirulina extracts might inhibit bacterial motility, invasion, biofilm formation, and quorum sensing in addition to acting directly on the bacterium by weakening and making the bacterial cell walls more porous, subsequently resulting in cytoplasmic content leakage. Additionally, Spirulina has shown antiviral activities against certain common human or animal viruses and this capability can be considered to exhibit potential benefits against avian viruses also. Spirulan, a calcium-rich internal polysaccharide of Spirulina, is potentially responsible for its antiviral effect through inhibiting the entry of several viruses into the host cells, boosting the production of nitric oxide in macrophages, and stimulating the generation of cytokines. Comparatively a greater emphasis has been given to the immune modulatory effects of Spirulina as a feed additive in chicken which might boost disease resistance and improve survival and growth rates, particularly under stress conditions. This manuscript reviews biological activities and immune-stimulating properties of Spirulina and its potential use as a dietary supplement in poultry to enhance growth, gut health and disease resistance.