Three new tirucallane triterpenoids from the fruits of Chukrasia tabularis and their biological activities
文献类型： 外文期刊
作者： Hu, Jia-Meng 1 ; Chen, Hui-Qin 2 ; Dong, Xuan 1 ; Wang, Hao 2 ; Dai, Hao-Fu 2 ; Gai, Cui-Juan 2 ; Wei, Yan-Mei 2 ; Cheng, 1 ;
作者机构： 1.Hainan Univ, Key Lab Genet & Germplasm Enhancement Trop Specif, Minist Educ,Coll Forestry, Hainan Key Lab Biol Trop Specif Ornamental Plants, Haikou 570228, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Product Li Folk Med, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Haikou 570228, Hainan, Peoples R China
3.China West Normal Univ, Coll Life Sci, Nanchong 637002, Peoples R China
关键词： Chukrasia tabularis; Tirucallane triterpenoid; Cytotoxic activity; Anti-inflammatory activity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）
ISSN： 1874-3900
年卷期： 2021 年 43 卷
页码：
收录情况： SCI
摘要： Three new triterpenoids (1-3), including two new 19 (10 -> 9 beta) abeo-tirucallane derivatives (1-2) and a new tirucallane-type triterpenoid (3), together with two known tirucallane-type triterpenoids (4-5) were isolated from the ethanol extract of the fruits of Chukrasia tabularis. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic analyses and MS data. The isolated triterpenoids 1 and 2 exhibited anti-inflammatory activities with IC50 values of 75.98 +/- 2.12 and 24.86 +/- 1.16 mu M, respectively. Compound 5 showed cytotoxic activities against the selected tumor cell lines.
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