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Structures and biological activities of brominated azaphilones produced by Penicillium sclerotiorum E23Y-1A

文献类型： 外文期刊

作者： Wang, Zhi 1 ; Zeng, Yanbo 2 ; Zhao, Weibo 1 ; Dai, Haofu 2 ; Chang, Wenjun 2 ; Lv, Fang 1 ;

作者机构： 1.Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceut, Beijing, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliza, Haikou, Peoples R China

关键词： Penicillium sclerotiorum; Structure elucidation; Azaphilones; Antibacterial activity; Acetylcholinesterase inhibition activity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）

ISSN： 1874-3900

年卷期： 2022 年 52 卷

页码：

收录情况： SCI

摘要： Two new brominated azaphilones, 5-bromoisorotiorin (1) and penicilazaphilones H (2), along with a known azaphilone, 5-bromosclerotiorin (3) were isolated from the marine-derived fungus Penicillium sclerotiorum E23Y-1A cultivated on the solid rice medium with 3.3%NaBr. The structures of three compounds were eluci-dated based on 1D and 2D NMR spectra as well as HRESIMS data. Their absolute configurations were determined by ECD spectra analysis. Compounds 1-3 showed moderate antibacterial activities against Staphylococcus aureus ATCC 25923 with diameter of the inhibition zones of 8.08 +/- 0.01, 7.50 +/- 0.05 and 8.17 +/- 0.05 mm, respec-tively, as well as compound 3 exhibited weak inhibitory activity against AChE.

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