Whole-Genome Sequence Analysis of Pseudorabies Virus Clinical Isolates from Pigs in China between 2012 and 2017 in China
文献类型： 外文期刊
作者： Hu, Ruiming 1 ; Wang, Leyi 4 ; Liu, Qingyun 1 ; Hua, Lin 1 ; Huang, Xi 1 ; Zhang, Yue 1 ; Fan, Jie 1 ; Chen, Hongjian 1 ; So 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Vet Med, Cooperat Innovat Ctr Sustainable Pig Prod, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
2.Jiangxi Agr Univ, Coll Anim Sci & Technol, Dept Vet Med, Nanchang 330045, Jiangxi, Peoples R China
3.Jiangxi Agr Univ, Jiangxi Prov Key Lab Anim Hlth, Nanchang 330045, Jiangxi, Peoples R China
4.Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61802 USA
5.Univ Illinois, Coll Vet Med, Vet Diagnost Lab, Urbana, IL 61802 USA
6.Minist Agr, Anim Husb & Vet Inst, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Acad Agr Sci, Wuhan 430070, Peoples R China
7.Jiangxi Agr Univ, State Key Lab Pig Genet Improvement & Prod Techno, Nanchang 330045, Jiangxi, Peoples R China
8.State Key Lab Food Safety Technol Meat Prod, Xiamen 360000, Peoples R China
9.Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China
关键词： pseudorabies virus; genome; phylogeny; recombination; selection pressure
期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）
ISSN：
年卷期： 2021 年 13 卷 7 期
页码：
收录情况： SCI
摘要： Pseudorabies virus (PRV) is an economically significant swine infectious agent. A PRV outbreak took place in China in 2011 with novel virulent variants. Although the association of viral genomic variability with pathogenicity is not fully confirmed, the knowledge concerning PRV genomic diversity and evolution is still limited. Here, we sequenced 54 genomes of novel PRV variants isolated in China from 2012 to 2017. Phylogenetic analysis revealed that China strains and US/Europe strains were classified into two separate genotypes. PRV strains isolated from 2012 to 2017 in China are highly related to each other and genetically close to classic China strains such as Ea, Fa, and SC. RDP analysis revealed 23 recombination events within novel PRV variants, indicating that recombination contributes significantly to the viral evolution. The selection pressure analysis indicated that most ORFs were under evolutionary constraint, and 19 amino acid residue sites in 15 ORFs were identified under positive selection. Additionally, 37 unique mutations were identified in 19 ORFs, which distinguish the novel variants from classic strains. Overall, our study suggested that novel PRV variants might evolve from classical PRV strains through point mutation and recombination mechanisms.
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