文献类型： 外文期刊
作者： Zhang, Xinya 1 ; Yan, Maocang 3 ; Mu, Cuimin 1 ; Wu, Jiayan 3 ; Chen, Jiakang 1 ; Pan, Guangchen 1 ; Wang, Xuepeng 1 ;
作者机构： 1.Shandong Prov Engn Technol Res Ctr Anim Dis Contr, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An 271018, Shandong, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 272000, Peoples R China
3.Zhejiang Mariculture Res Inst, Zhejiang Key Lab Exploitat & Preservat Coastal Bi, Wenzhou Key Lab Marine Genet & Breeding, Wenzhou 325005, Peoples R China
关键词： Edwardsiella piscicida; FucP; T3SS; Fucose; Pathogenicity
期刊名称：AQUACULTURE REPORTS （ 2020影响因子：3.216； 五年影响因子：3.812 ）
ISSN： 2352-5134
年卷期： 2021 年 20 卷
收录情况： SCI
摘要： Edwardsiella piscicida (E. piscicida) is an important zoonotic pathogen that mostly infects fish by colonizing the intestine. Fucose within the intestine could regulate the pathogenicity of some intestinal pathogens. Here we identified the function of fucose permease in E. piscicida and its physiological influence. The results showed that E. piscicida grew faster in the presence of L-fucose. The fucose permease gene fucP mutant strain Delta fucP significantly decreased penetration and motility in mucin compared with the wild-type strain. The gene expression levels of esaB, esaD, esaL and esaK in Delta fucP had significantly downregulated when compared with the wild-type strain. Most importantly, the survival rate of zebrafish after being infected with Delta fucP was significantly higher than those of the wild type. In a word, fucose promoted the growth and motility of E. piscicida and the fucP gene mutant decreased the pathogenicity of E. piscicida in zebrafish.
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