文献类型： 外文期刊
作者： Zhou, Qian 1 ; Zhu, Xue 3 ; Li, Yangzhen 1 ; Yang, Pengshuo 3 ; Wang, Shengpeng 4 ; Ning, Kang 3 ; Chen, Songlin 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Marine Fisheries, Minist Agr, Qingdao 266071, Shandong, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Shandong, Peoples R China
3.Huazhong Univ Sci & Technol, Hubei Key Lab Bioinformat & Mol Imaging, Ctr AI Biol,Coll Life Sci & Technol, Key Lab Mol Biophys,Minist Educ,Dept Bioinformat, Wuhan 430074, Hubei, Peoples R China
4.Shandong Longchang Anim Hlth Prod Co Ltd, Dezhou Key Lab Appl Bile Acid Res, Shandong Lachance Co Ltd, Jinan 251100, Shandong, Peoples R China
期刊名称：MICROBIOME （ 影响因子：16.837； 五年影响因子：19.813 ）
ISSN： 2049-2618
年卷期： 2022 年 10 卷 1 期
页码：
收录情况： SCI
摘要： Background: Infectious diseases have caused huge economic loss and food security issues in fish aquaculture. Current management and breeding strategies heavily rely on the knowledge of regulative mechanisms underlying disease resistance. Though the intestinal microbial community was linked with disease infection, there is little knowledge about the roles of intestinal microbes in fish disease resistance. Cynoglossus semilaevis is an economically important and widely cultivated flatfish species in China. However, it suffers from outbreaks of vibriosis, which results in huge mortalities and economic loss. Results: Here, we used C. semilaevis as a research model to investigate the host-microbiome interactions in regulating vibriosis resistance. The resistance to vibriosis was reflected in intestinal microbiome on both taxonomic and functional levels. Such differences also influenced the host gene expressions in the resistant family. Moreover, the intestinal microbiome might control the host immunological homeostasis and inflammation to enhance vibriosis resistance through the microbe-intestine-immunity axis. For example, Phaeobacter regulated its hdhA gene and host cyp27a1 gene up-expressed in bile acid biosynthesis pathways, but regulated its trxA gene and host akt gene down-expressed in proinflammatory cytokines biosynthesis pathways, to reduce inflammation and resist disease infection in the resistant family. Furthermore, the combination of intestinal microbes and host genes as biomarkers could accurately differentiate resistant family from susceptible family. Conclusion: Our study uncovered the regulatory patterns of the microbe-intestine-immunity axis that may contribute to vibriosis resistance in C. semilaevis. These findings could facilitate the disease control and selective breeding of superior germplasm with high disease resistance in fish aquaculture.
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