您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Plasmonic polydopamine-modified TiO2 nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging

文献类型： 外文期刊

作者： Chen, Dong 1 ; Du, Mingyi 1 ; Huang, Yudi 1 ; Xu, Yizhu 1 ; Chen, Yingying 1 ; Ma, Lianlian 1 ; Xie, Qingrong 1 ; Zhu, Xinhai 4 ; Chen, Zilong 4 ; Xu, Hanhong 1 ; Wu, Xinzhou 1 ; Yin, Zhibin 3 ;

作者机构： 1.South China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Key Lab Nat Pesticide & Chem Biol, Minist Educ, Guangzhou 510642, Peoples R China

3.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Peoples R China

4.Sun Yat Sen Univ, Instrumental Anal & Res Ctr, Guangzhou 510275, Peoples R China

关键词： TiO2 nanotube; surface-assisted laser desorption; ionization (SALDI); mass spectrometry imaging; latent fingerprint; tissue imaging

期刊名称：NANO RESEARCH （ 影响因子：10.269； 五年影响因子：9.24 ）

ISSN： 1998-0124

年卷期：

页码：

收录情况： SCI

摘要： Mass spectrometry imaging (MSI) has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible. However, available matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) suffers from severe background interferences in low-mass ranges and inhomogeneous matrix deposition. Thus, surface-assisted LDI-MS (SALDI-MS) has been an attractive alternative for high-sensitivity detection and imaging of small biomolecules. In this study, we construct a new composite substrate, hydrophobic polydopamine (hPDA)-modified TiO2 nanotube (TDNT) coated with plasmonic gold nanoparticle (AuNP-hPDA-TDNT), as a dual-polarity SALDI substrate using an easy and cost-effective fabrication approach. Benefitting from the synergistic effects of TDNT semiconductor and plasmonic PDA modification, this SALDI substrate exhibits superior performance for dual-polarity detection of a vast diversity of small molecules. Highly reduced background interferences, lower detection limits, and spot-to-spot repeatability can be achieved using AuNP-hPDA-TDNT substrates. Due to its unique imprinting performance, various metabolites and lipids can be visualized within jatropha integerrima petals, ginkgo leaves, strawberry fruits, and latent fingerprints. More valuably, the universality of this matrix-free substrate is demonstrated for mapping spatial distribution of lipids within mouse brain tissue sections. Considered together, this AuNP-hPDA-TDNT material is expected to be a promising SALDI substrate in various fields, especially in nanomaterial development and life sciences.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台