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Tralopyril affects locomotor activity of zebrafish (Danio rerio) by impairing tail muscle tissue, the nervous system, and energy metabolism

文献类型： 外文期刊

作者： Chen, Xiangguang 1 ; Zheng, Junyue 1 ; Teng, Miaomiao 2 ; Zhang, Jie 1 ; Qian, Le 1 ; Duan, Manman 1 ; Cheng, Yi 1 ; Zhao, Wentian 1 ; Wang, Zhao 3 ; Wang, Chengju 1 ;

作者机构： 1.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Beijing 100193, Peoples R China

2.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China

3.Jilin Acad Agr Sci, Inst Plant Prod, Changchun 130033, Peoples R China

关键词： Antifouling biocide; Tralopyril; Metabolomics; Neurodevelopment

期刊名称：CHEMOSPHERE （ 影响因子：8.943； 五年影响因子：8.52 ）

ISSN： 0045-6535

年卷期： 2022 年 286 卷

页码：

收录情况： SCI

摘要： Tralopyril (TP), an antifouling biocide, is widely used to prevent heavy biofouling, and can have potential risks to aquatic organisms. In this study, the effect of TP on locomotor activity and related mechanisms were evaluated in zebrafish (Danio rerio) larvae. TP significantly reduced locomotor activity after 168 -h exposure. Adverse modifications in tail muscle tissue, the nervous system, and energy metabolism were also observed in larvae. TP caused thinning of the muscle bundle in the tail of larvae. In conjunction with the metabolomics results, changes in dopamine (DA) and acetylcholine (ACh), acetylcholinesterase (AChE) activity, and the expression of genes involved in neurodevelopment, indicate that TP may disrupt the nervous system in zebrafish larvae. The change in metabolites (e.g., glucose 6-phosphate, cis-Aconitic acid, acetoacetyl-CoA, coenzyme-A and 3-OxohexanoylCoA) involved in carbohydrate and lipid metabolism indicates that TP may disrupt energy metabolism. TP exposure may inhibit the locomotor activity of zebrafish larvae by impairing tail muscle tissue, the nervous system, and energy metabolism.

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