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Multi-model risk assessment of pesticide residues in seasonal fruits based on integrated targeted/non-targeted screening: Implications for vulnerable populations

文献类型： 外文期刊

作者： Si, Wenshuai 1 ; Song, Yiqing 3 ; Guo, Can 1 ; Huang, Zhiying 1 ; Chen, Lei 1 ; Xu, Fei 2 ; Bai, Bing 1 ; Huo, Kaixuan 3 ; Wang, Shouying 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing Technol, 1000 Jinqi Rd, Shanghai 201403, Peoples R China

2.Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China

3.Shanghai Coelite Agrifood Testing Tech Serv Co Ltd, 1000 Jinqi Rd, Shanghai 201403, Peoples R China

关键词： Cumulative risk assessment; Vulnerable groups; Pesticide residues; Fruits; RPF/HI models

期刊名称：FOOD CHEMISTRY-X （ 影响因子：8.2； 五年影响因子：8.2 ）

ISSN： 2590-1575

年卷期： 2025 年 28 卷

页码：

收录情况： SCI

摘要： This study comprehensively analyzed multiple pesticide residues and their characteristics in commercially available fruits using integrated targeted and non-targeted techniques, with a focus on assessing health risks for children and pregnant women based on cumulative dietary risk models. Results showed 745 samples (7 categories) identified 54 pesticides (88.6 % detection rate; 1.1 % exceeding legal limits), with strawberries and peaches of the highest detection rates (98 %), and grapes the most diverse residues (avg. 6/sample). Risk ranking analysis flagged difenoconazole and indoxacarb as high-risk. Chronic cumulative exposure risks were dominated by hepatotoxic triazole fungicides. Acute risk assessments revealed potential hepatotoxicity concerns for children (3-6 years) and pregnant women consuming grapes/peaches. The Relative Potency Factor (RPF) model, accounting for synergism, showed 4-7 times higher neuro/hepatotoxicity risks than the Hazard Index (HI) model. This first integration of non-targeted screening with multi-model risk assessment provides evidence for strengthening pesticide regulation and protecting sensitive subpopulations.

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