文献类型： 外文期刊
作者： Chen, Leyao 1 ; Chen, Huiqin 2 ; Cai, Caihong 2 ; Yuan, Jingzhe 2 ; Gai, Cuijuan 2 ; Liu, Shoubai 1 ; Mei, Wenli 2 ; Dai, Haofu 2 ;
作者机构： 1.Hainan Univ, Sch Forestry, Haikou 570228, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Haikou 571101, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, 4 Xueyuan Rd, Haikou 571101, Hainan, Peoples R China
关键词： Aquilaria walla; Agarwood; Flavonoid-2-(2-phenylethyl)chromone; 2-(2-phenylethyl)chromone dimer; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）
ISSN： 0367-326X
年卷期： 2023 年 165 卷
页码：
收录情况： SCI
摘要： Two rare flavonoid-2-(2-phenylethyl)chromones and five new dimeric 2-(2-phenylethyl)chromones were isolated from ethanol extract of agarwood of Aquilaria walla by LC-MS-guided fractionation procedure. Their structures were established based on extensive spectroscopic methods including HRESIMS, 1D and 2D NMR, as well as by comparison with the literature. Compound 1 showed cytotoxic activity against five human cancer cell lines with IC50 values ranging from 13.40 to 28.96 mu M with cisplatin as the positive control.
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