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Characterization and expression patterns of lysozymes reveal potential immune functions during male pregnancy of seahorse

文献类型： 外文期刊

作者： Xiao, Wanghong 1 ; Gu, Na 3 ; Zhang, Bo 4 ; Liu, Ying 5 ; Zhang, Yanhong 1 ; Zhang, Zhixin 1 ; Qin, Geng 1 ; Lin, Qiang 1 ;

作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510300, Peoples R China

2.Sanya Inst Ocean Ecoenvironm Engn, Sanya 572000, Peoples R China

3.Zhongkai Univ Agr & Engn, Guangzhou 510225, Peoples R China

4.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Minist Agr, Guangzhou 510300, Peoples R China

5.Tianjin Agr Univ, Coll Fisheries, Key Lab Aquat Ecol & Aquaculture Tianjin, Tianjin 300384, Peoples R China

关键词： Seahorse; Lysozyme; Male pregnancy; Brood pouch; Immune protection

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：2.9； 五年影响因子：3.1 ）

ISSN： 0145-305X

年卷期： 2023 年 142 卷

页码：

收录情况： SCI

摘要： Seahorses are one of the most amazing ovoviviparous fishes in the ocean because males, and not females, have evolved a brood pouch for incubating embryos. During male pregnancy, paternal seahorses need to develop effective immune protection for embryos in the brood pouch from potential infection by pathogens. Lysozymes (Lyz) are a group of antibacterial enzymes of the innate immune system that play an important role in resisting pathogen invasion. However, the immune function of lysozymes in the brood pouch of the pregnancy-lined seahorse (Hippocampus erectus) remains unknown. In this study, we found three different lysozymes in the lined seahorse: HeLyzC, HeLyzG1, and HeLyzG2. Synteny analysis revealed that HeLyzG1 and HeLyzG2 were generated by species-specific expansion rather than tandem duplication. Tissue expression patterns showed that the highest mRNA expression levels of the three lysozymes occurred in the brood pouches. Immunostimulationinduced expression analysis showed that all three HeLyzs in the brood pouches up-regulated their mRNA expression levels after Vibrio parahaemolyticus infection, but only the HeLyzG2 was upregulated after Poly(I:C) injection. Similarly, except for HeLyzC, upregulated expressions of HeLyzG1 and HeLyzG2 were found quickly in brood pouches injected with LPS. The upregulated levels of HeLyzC and HeLyzG2 in brood pouches during pregnancy were significantly higher than those in non-pregnancy, implying that seahorse lysozymes might function in the immune defense in brood pouches during pregnancy. In addition, the expression levels of HeLyzs were low in embryos in the brood pouch but significantly increased in neonates. This implies that embryos in the brood pouch might not necessarily express more lysozymes by themselves due to paternal immune protection. In conclusion, our study demonstrated that HeLyzs play an important role in immune protection during male seahorse gestation, and the synergistic effect of multiple HeLyzs may contribute to improved neonatal survival.

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