Three new tetrahydrobenzofuran derivatives from Ferula sinkiangensis KMShen and their cytotoxic activities
文献类型： 外文期刊
作者： Yi, Xianguo 1 ; Li, Zhili 1 ; Zheng, Quanfang 1 ; Sang, Ruijuan 1 ; Li, Haili 2 ; Gao, Ge 1 ; Qin, Qingming 1 ; Zhu, Nailiang 1 ;
作者机构： 1.Xinyang Agr & Forestry Univ, Pharmacet Engn, Xinyang, Henan, Peoples R China
2.Henan Acad Agr Sci, Anim Husb & Vet Res Inst, Zhengzhou, Henan, Peoples R China
关键词： Ferula sinkiangensis; tetrahydrobenzofuran derivatives; cytotoxic activities; AGS cell lines
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.488； 五年影响因子：2.51 ）
ISSN： 1478-6419
年卷期：
页码：
收录情况： SCI
摘要： Phytochemical investigation the resins of Ferula sinkiangensis K.M.Shen yielded three new tetrahydrobenzofuran derivatives named as Sinkiangensis A-C (1-3). The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. Compound 3 exhibited moderate antitumor activities against AGS cancer cell with IC50 values of 15.6 mu M. Moreover, assays demonstrated that compound 3 could induce AGS cancer cell apoptosis.
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