PRRSV NSP1α degrades TRIM25 through proteasome system to inhibit host antiviral immune response
文献类型： 外文期刊
作者： Zheng, Yuhang 1 ; Jiang, Dandan 4 ; Sui, Chao 5 ; Wu, Xiangju 4 ; Hu, Yue 4 ; Lee, Changhee 8 ; Cong, Xiaoyan 4 ; Li, Juntong 4 ; Lu, Yu 2 ; Wang, Zhao 1 ; Du, Yijun 1 ; Qi, Jing 1 ; Huang, Juan 1 ;
作者机构： 1.Qingdao Agr Univ, Coll Vet Med, Qingdao 266109, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Peoples R China
3.GuoTai Taizhou Ctr Technol Innovat Vet Biol, Nanjing 210014, Peoples R China
4.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Key Lab Livestock & Poultry Multi MARA, Jinan 250100, Peoples R China
5.Shandong Univ, Qilu Hosp, Lab Anim Ctr, Jinan 250012, Peoples R China
6.Shandong First Med Univ & Shandong Acad Med Sci, Sch Lab Anim, Jinan, Peoples R China
7.Shandong First Med Univ & Shandong Acad Med Sci, Shandong Lab Anim Ctr, Jinan 250118, Peoples R China
8.Gyeongsang Natl Univ, Coll Vet Med, Virus Vaccine Res Ctr, Jinju 52828, South Korea
关键词： PRRSV NSP1 alpha; TRIM25; Proteasome system; Antiviral response
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：2.4； 五年影响因子：2.6 ）
ISSN： 0378-1135
年卷期： 2024 年 296 卷
页码：
收录情况： SCI
摘要： Porcine reproductive and respiratory syndrome (PRRS) is the most economically significant disease caused by porcine reproductive and respiratory syndrome virus (PRRSV). Type I interferon (IFN) induces a large number of interferon-stimulated genes (ISGs) expression to inhibit PRRSV infection. To survive in the host, PRRSV has evolved multiple strategies to antagonize host innate immune response. Previous studies have reported that PRRSV N protein decreases the expression of TRIM25 and TRIM25-mediated RIG-I ubiquitination to suppress IFN-beta production. However, whether other PRRSV proteins inhibit the antiviral function of TRIM25 is less well understood. In this study, we first found that PRRSV NSP1 alpha decreased ISGylation of TRIM25. Meanwhile, NSP1 alpha significantly suppressed TRIM25-mediated IFN-beta production to promote PRRSV replication. Further studies demonstrated that PRRSV NSP1 alpha reduced the protein level of TRIM25 in proteasome system but did not regulate the transcription level of TRIM25. In addition, the function of NSP1 alpha in TRIM25 degradation did not rely on its papain-like cysteine protease activity. Taken together, PRRSV NSP1 alpha antagonizes the antiviral response of TRIM25 by mediating TRIM25 degradation to promote PRRSV replication. Our data identify TRIM25 as a natural target of PRRSV NSP1 alpha and reveal a novel mechanism that PRRSV induces TRIM25 degradation and inhibits host antiviral immune response.
- 相关文献
作者其他论文 更多>>
-
Alginate di-aldehyde-modified metal-organic framework nanocarriers as delivery platform and adjuvant in inactivated pseudorabies vaccination
作者：Yin, Wenzhu;Chang, Chen;Zhao, Yanhong;Wang, Haiyan;Zhang, Jinqiu;Ma, Fang;Zuo, Xiaoxin;Tang, Bo;Lu, Yu;Yin, Wenzhu;Xu, Zeyu;Tang, Bo;Yin, Wenzhu;Lu, Yu
关键词：
-
Cistanche deserticola polysaccharide- functionalized dendritic fibrous nano-silica- based adjuvant for H 9 N 2 oral vaccine enhance systemic and mucosal immunity in chickens
作者：He, Jin;Lu, Xuanqi;Mao, Ningning;Zhu, Tianyu;Yu, Lin;Yu, Yaming;Peng, Song;Deng, Xiangwen;Hu, Bing;Wang, Deyun;Lu, Yu;Jiang, Wenming
关键词：Oral vaccine; Dendritic fibrous nano-silica; Adjuvant; Mucosal and systemic immunity; cetyltrimethylammonium bromide (CTAB); triethanolamine (TEA); sodium salicylate (Nasal); tetraethoxysilane (TEOS); 3-aminopropyltriethoxysilane (APTES); 1-Ethyl-3-(3-dimethylaminopropyl); carbodiimide(EDC & sdot;HOL); N-Hydroxy succinimide (NHS); Lipopolysaccharide (LPS); phytohaemagglutinin (PHA); Cistanche deserticola polysaccharide (CDP)
-
Thermostable vacuum foam dried Newcastle disease vaccine: Process optimization and pilot-scale study
作者：Lyu, Fang;Zhao, Yan-hong;Zuo, Xiao-xin;Deng, Bi-hua;Zhou, Ming-xu;Hou, Jibo;Jiao, Jia-jie;Zeng, Min-qian;Jie, Hong-ying;Lu, Yu;Lyu, Fang;Nyide, Babalwa;Khoza, Thandeka;Olaniran, Ademola;Lyu, Fang;Deng, Bi-hua;Zhou, Ming-xu;Lu, Yu;Lyu, Fang;Zhao, Yan-hong;Deng, Bi-hua;Jiao, Jia-jie;Zeng, Min-qian;Lu, Yu;Zuo, Xiao-xin;Lu, Yu
关键词：Vacuum foam drying; Process upscaling; NDV vaccine; Thermostability
-
Matrine Ameliorates DSS-Induced Colitis by Suppressing Inflammation, Modulating Oxidative Stress and Remodeling the Gut Microbiota
作者：Mao, Ningning;Yu, Yaming;He, Jin;Yang, Yang;Liu, Zhenguang;Wang, Deyun;Mao, Ningning;Yu, Yaming;He, Jin;Yang, Yang;Liu, Zhenguang;Wang, Deyun;Lu, Yu
关键词：DSS; matrine; ulcerative colitis; Treg/Th17; gut microbiota
-
Mathematical modeling of temperature and natural antimicrobial effects on germination and outgrowth of Clostridium perfringens in chilled chicken
作者：Wang, Wenzhuo;Wang, Daoying;Zheng, Yuhang;Liu, Fang;Sun, Zhilan;Mai, Xutao;Liu, Fang;Sun, Zhilan;Wang, Wenzhuo;Zheng, Yuhang;Wang, Daoying;Liu, Fang;Sun, Zhilan;Mai, Xutao
关键词：Ginger essential oil; Grape seed extract; Clostridium perfringens; Shelf-life; Kinetic models
-
Novel PVA/carboxylated cellulose antimicrobial hydrogel grafted with curcumin and epsilon-polylysine for chilled chicken preservation
作者：Mai, Xutao;Zhang, Xinxiao;Wang, Wenzhuo;Zheng, Yuhang;Wang, Daoying;Xu, Weimin;Sun, Zhilan;Wang, Daoying;Liu, Fang;Wang, Daoying;Sun, Zhilan;Mai, Xutao;Xu, Weimin
关键词：Carboxylated cellulose; Curcumin; epsilon-Polylysine; Bactericidal activity; Graft
-
Formulation and Evaluation of Lipidized Imiquimod as an Effective Adjuvant
作者：Yin, Wenzhu;Deng, Bihua;Wang, Haiyan;Ma, Fang;Zhou, Mingxu;Lu, Yu;Zhang, Jinqiu;Xu, Zeyu;Lu, Yu;Zhang, Jinqiu
关键词：adjuvant; imiquimod; cholesterol; liposolubility; foot-and-mouth disease
