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Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells

文献类型： 外文期刊

作者： Wang, Dan 1 ; Wan, Xuebin 1 ; Du, Xiaoli 1 ; Zhong, Zhuxia 1 ; Peng, Jian 4 ; Xiong, Qi 5 ; Chai, Jin 1 ; Jiang, Siwen 1 ;

作者机构： 1.Huazhong Agr Univ, Key Lab Swine Breeding & Genet, Minist Educ, Agr Minist, Wuhan 430070, Peoples R China

2.Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China

3.Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China

4.Huazhong Agr Univ, Dept Anim Nutr, Wuhan 430070, Peoples R China

5.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Hubei Key Lab Anim Embryo Engn & Mol Breeding, Wuhan 430070, Peoples R China

关键词： amino acid transporter; lysosome; leucine; mTORC1 signaling pathway

期刊名称：BIOMOLECULES （ 影响因子：4.879； 五年影响因子：5.362 ）

ISSN：

年卷期： 2021 年 11 卷 9 期

页码：

收录情况： SCI

摘要： Amino acids are critical for mammalian target of rapamycin complex 1 (mTORC1) activation on the lysosomal surface. Amino acid transporters SLC38A9 and SLC36A1 are the members of the lysosomal amino acid sensing machinery that activates mTORC1. The current study aims to clarify the interaction of SLC38A9 and SLC36A1. Here, we discovered that leucine increased expressions of SLC38A9 and SLC36A1, leading to mTORC1 activation. SLC38A9 interacted with SLC36A1 and they enhanced each other's expression levels and locations on the lysosomal surface. Additionally, the interacting proteins of SLC38A9 in C2C12 cells were identified to participate in amino acid sensing mechanism, mTORC1 signaling pathway, and protein synthesis, which provided a resource for future investigations of skeletal muscle mass.

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