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Autophagy and Mitochondrial Homeostasis During Infection: A Double-Edged Sword

文献类型： 外文期刊

作者： Wang, Sutian 1 ; Zhang, Kunli 2 ; Yao, Yuchang 3 ; Li, Jianhao 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangdong Prov Key Lab Livestock Dis Prevent Guan, Guangzhou, Peoples R China

3.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China

4.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Maoming, Peoples R China

关键词： autophagy; homeostasis; dual role; pathogen infection; mitochondria

期刊名称：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY （ 影响因子：6.684； 五年影响因子：7.219 ）

ISSN： 2296-634X

年卷期： 2021 年 9 卷

页码：

收录情况： SCI

摘要： Autophagy, an essential biological process that affects immunity, is a powerful tool that host cells can use to defend against infections caused by pathogenic microorganisms. Autophagy can not only initiate innate immune responses but also degrade the cellular components that provide the conditions for removing the invaders. However, hyperactivated or inhibited autophagy leads to mitochondrial dysfunction, which is harmful to the host itself and is involved in many types of diseases. Mitochondria perform the functions of biological oxidation and energy exchange. In addition, mitochondrial functions are closely related to cell death, oxygen radical formation, and disease. Accumulation of mitochondrial metabolites affects survival of intracellular pathogens. In this mini-review, we focus on the crosstalk between autophagy and mitochondrial homeostasis during infection.

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